ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor?
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis.Mediators of inflammation · 2015Pooled it
- Lunate bone loss associated withTrauma case reports · 2021Article
- Oxidative Stress and Inflammation in SARS-CoV-2- andBiomedicines · 2021Review
- Interferon-γ Possesses Anti-Microbial and Immunomodulatory Activity on aMicroorganisms · 2020Article
- Review
- No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis.The Journal of international medical research · 2019Article
- Infectious Agents in Atherosclerotic Cardiovascular Diseases through Oxidative Stress.International journal of molecular sciences · 2017Review
- Productive and Penicillin-StressedFrontiers in cellular and infection microbiology · 2017Article
- Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study.Journal of bone and mineral metabolism · 2016Article
- Effects of Mentha suaveolens essential oil on Chlamydia trachomatis.BioMed research international · 2015Article
- Chlamydia pneumoniae Clinical Isolate from Gingival Crevicular Fluid: A Potential Atherogenic Strain.Frontiers in cellular and infection microbiology · 2015Article
- Chlamydia pneumoniae and oxidative stress in cardiovascular disease: state of the art and prevention strategies.International journal of molecular sciences · 2014Review
- Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae.BMC immunology · 2014Article
- Infectious burden and atherosclerosis: A clinical issue.World journal of clinical cases · 2014Review
- Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: a brief overview.International journal of molecular sciences · 2013Review
- Evidence for horizontal gene transfer betweenBacteriophageArticle
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledWe found an association between the presence of Chlamydia pneumoniae DNA both in osteoporotic bone tissue and peripheral blood mononuclear cells (PBMCs) and the increase in circulating resorptive cytokines.
introductionOur study was designed to determine whether C. pneumoniae infection may be involved in osteoporosis-associated bone loss.
methodsThe study included 59 women undergoing hip joint replacement surgery for femoral neck fracture: 32 with osteoporosis and 27 with osteoarthritis. A total of 118 tissue specimens (59 bone tissues, 59 PBMCs) were examined for C. pneumoniae DNA by real-time polymerase chain reaction (PCR). Serum levels of soluble receptor activator of nuclear factor kappa B ligand (sRANKL), osteoprotegerin (OPG), interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 were also measured.
resultsC. pneumoniae DNA was detected in osteoporotic bone tissue whereas it was not found in non-osteoporotic bone tissue (p < 0.05). A significantly higher rate of C. pneumoniae DNA (p < 0.05) was found in PBMCs of osteoporotic patients than in those of osteoarthritis patients. Among osteoporotic patients, serum sRANKL, IL-1, and IL-6 concentrations as well as sRANKL/OPG ratio significantly differ between patients with bone tissue and PBMCs positive to C. pneumoniae and C. pneumoniae-negative patients.
conclusionThe association between the presence of C. pneumoniae DNA, both in bone tissue and PBMCs, and the increase in sRANKL/OPG ratio as well as in IL-1β and IL-6 levels observed in osteoporotic patients suggests C. pneumoniae infection as a new risk factor for osteoporosis.
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