Trial reportSocial cognitive and affective neuroscience2014
Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection.
Trial report in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Neurofunctional representations of instrumental learning in psychosis: a meta-analysis of neuroimaging studies.Psychological medicine · 2025Pooled it
- Activation of the motivation-related ventral striatum during delusional experience.Translational psychiatry · 2018Pooled it
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Trait paranoia shapes inter-subject synchrony in brain activity during an ambiguous social narrative.Nature communications · 2018Article
- Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non-Help-Seeking Population.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Individual variation in functional brain connectivity: implications for personalized approaches to psychiatric disease.Dialogues in clinical neuroscience · 2016Review
- Distribution of Response Time, Cortical, and Cardiac Correlates during Emotional Interference in Persons with Subclinical Psychotic Symptoms.Frontiers in behavioral neuroscience · 2016Article
- Examining the Psychosis Continuum.Current behavioral neuroscience reports · 2015Article
- Me, myself and I: temporal dysfunctions during self-evaluation in patients with schizophrenia.Social cognitive and affective neuroscience · 2014Article
- Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions.Schizophrenia research · 2014Article
- Widespread brain dysconnectivity associated with psychotic-like experiences in the general population.NeuroImage. Clinical · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Neuroimaging studies have demonstrated associations between delusions in psychotic disorders and abnormalities of brain areas involved in social cognition, including medial prefrontal cortex (MPFC), posterior cingulate cortex, and lateral temporal cortex (LTC). General population studies have linked subclinical delusional thinking to impaired social cognition, raising the question of whether a specific pattern of brain activity during social perception is associated with delusional beliefs. Here, we tested the hypothesis that subclinical delusional thinking is associated with changes in neural function, while subjects made judgments about themselves or others ['social reflection' (SR)]. Neural responses during SR and non-social tasks, as well as resting-state activity, were measured using functional magnetic resonance imaging in 22 healthy subjects. Delusional thinking was measured using the Peters et al. Delusions Inventory. Delusional thinking was negatively correlated with responses of the left LTC during SR (r = -0.61, P = 0.02, Bonferroni corrected), and connectivity between the left LTC and left ventral MPFC, and was positively correlated with connectivity between the left LTC and the right middle frontal and inferior temporal cortices. Thus, delusional thinking in the general population may be associated with reduced activity and aberrant functional connectivity of cortical areas involved in SR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.