ArticleIn vivo (Athens, Greece)
The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Beyond the mouse: 3R-guided alternative animal models transforming cancer research.Molecular cancer · 2026Review
- Animals in Respiratory Research.International journal of molecular sciences · 2024Review
- Effect of adenosine treatment on ionizing radiation toxicity in zebrafish early life stages.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Using Zebrafish as a Disease Model to Study Fibrotic Disease.International journal of molecular sciences · 2021Review
- Protection of Coral Larvae from Thermally Induced Oxidative Stress by Redox Nanoparticles.Marine biotechnology (New York, N.Y.) · 2018Article
- Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion.Zebrafish · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
aimUse of zebrafish models may decrease the cost of screening new irradiation protectors and mitigators. MATERIALS AND
methodsZebrafish (Danio rerio) models were tested for screening water-soluble radiation protectors and mitigators. Irradiation of embryos and monitoring survival, and measuring fibrosis of the caudal musculature of adults allowed for testing of acute and late effects, respectively.
resultsIncubation of zebrafish embryos either before or after irradiation in ethyl pyruvate (1 mM) increased survival. Irradiation of adults to 15 to 75 Gy, delivered in single-fraction at 13 Gy/min, showed dose-dependent fibrosis at 30 days, quantitated as physiological decrease in swimming tail movement, and histopathological detection of collagen deposition in the dorsal musculature. Continuous administration of small-molecule radioprotector drugs in the water after irradiation reduced both acute and chronic injuries.
conclusionThe zebrafish is cost-effective for screening new radiation countermeasures.
Indexed as
Identifiers
23160669PMC3775014What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.