ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2013
Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
- Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.Frontiers in cell and developmental biology · 2021Review
- Deleterious mutations show increasing negative effects with age in Drosophila melanogaster.BMC biology · 2020Article
- Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult FemaleFrontiers in genetics · 2018Article
- Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.Annals of the New York Academy of Sciences · 2017Review
- Testing evolutionary models of senescence: traditional approaches and future directions.Human genetics · 2014Review
- A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation.Evolution; international journal of organic evolution · 2014Article
- Amelioration of reproduction-associated oxidative stress in a viviparous insect is critical to prevent reproductive senescence.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Populations of Drosophila melanogaster that have been artificially selected for late age of reproduction evolve longer life spans and, in some cases, reduced early fecundity. The negative correlation is widely interpreted as evidence of antagonistic pleiotropy. Here, we show that the correlation breaks down in recombinant genomes. A major quantitative trait locus that increases adult life span by 20% has no detectable effect on early fecundity. Several recombinant genotypes are superflies, exhibiting both elevated early fecundity and long life. The genetic correlation of early fecundity and life span is not different from zero, while the midlife fecundity correlation is positive and statistically significant, suggesting age-specific adaptation. The results are not consistent with a dominant role for negative pleiotropy, but can be understood in terms of a mixture of pleiotropic and recombining nonpleiotropic elements. Life span and early fecundity can be genetically uncoupled.
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Registered trials
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