ReviewCurrent opinion in allergy and clinical immunology2013
The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation.
Review in Current opinion in allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Δ9-Tetrahydrocannabinol exposure shifts eosinophil and macrophage transcriptional programs toward an anti-inflammatory phenotype in helminth infection.Journal of leukocyte biology · 2026Article
- A comprehensive evaluation of murine and humanERJ open research · 2025Article
- Eosinophils in inflammatory bowel disease pathogenesis: an ROS-centric view.Frontiers in allergy · 2025Article
- CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- NLRC4 Inflammasome-Mediated Regulation of Eosinophilic Functions.Immune network · 2021Article
- Sialic acids as cellular markers of immunomodulatory action of dexamethasone on glioma cells of different immunogenicity.Molecular and cellular biochemistry · 2019Article
- Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency.Glycobiology · 2018Article
- FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.Journal of immunological methods · 2018Article
- Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions.Frontiers in immunology · 2018Review
- Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection.Frontiers in immunology · 2018Observational
- Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy.The Journal of experimental medicine · 2017Article
- Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- "Siglec"ting the allergic response for therapeutic targeting.Glycobiology · 2016Review
- Immortalized MH-S cells lack defining features of primary alveolar macrophages and do not support mouse pneumovirus replication.Immunology letters · 2016Article
- Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.Current opinion in allergy and clinical immunology · 2016Review
- Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.The Journal of allergy and clinical immunology · 2015Article
- Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.The Journal of allergy and clinical immunology · 2015Article
- Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation.The Journal of allergy and clinical immunology · 2015Review
- Siglec-mediated regulation of immune cell function in disease.Nature reviews. Immunology · 2014Review
- Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.Immunology letters · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewSiglec-8 and Siglec-F are single pass transmembrane inhibitory receptors found on the surface of human and mouse eosinophils, respectively, but very little is known about their physiologic glycan ligands. This article reviews the latest knowledge on this topic and outlines the strategies being used to further define the production and glycobiochemical nature of these molecules in the lung. RECENT
findingsBoth Siglec-8 and Siglec-F recognize the same glycan structure, namely 6'-sulfated sialyl Lewis X, as determined using glycan array technologies. Studies have identified α2,3-linked sialylated glycoprotein structures localized to mouse airway epithelium in tissue sections, where their constitutive expression requires the specific sialyltransferase St3gal3. Expression of these ligands in lung is enhanced during allergic inflammation and by cytokines such as IL-13, and is maintained in primary air-liquid interface cultures of mouse lung epithelium. Further characterization suggests that they are high molecular weight sialylated proteins, putatively mucins. By combining analytic glycomics, glycoproteomic mapping, and further in-vitro eosinophil experimentation including the ability of candidate structures to enhance eosinophil apoptosis, a finely detailed appreciation of the structural requirements for productive Siglec-8 and Siglec-F engagement should soon emerge. SUMMARY: An enhanced understanding of Siglec-F, Siglec-8, and their ligands should improve our understanding of endogenous lung pathways limiting the survival of eosinophils within the airway in diseases such as asthma. Knowledge of this biology may also result in novel opportunities for drug development involving glycans and glycomimetics that selectively bind to Siglec-8 and induce eosinophil death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.