IL-2 and IL-15 signaling complexes: different but the same.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed.

1. PEG-RLI: A Long-Acting IL-15 Agonist That Produces Massive Levels of CD8Pharmaceutics · 2026
   Article
2. IL-15 signaling via cis- and trans-presentation to progenitor-exhausted CD8Journal of nanobiotechnology · 2025
   Article
3. Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis.The Journal of investigative dermatology · 2025
   Article
4. Structure and function of therapeutic antibodies approved by the US FDA in 2024.Antibody therapeutics · 2025
   Review
5. Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
   Article
6. Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy.Nature communications · 2023
   Article
7. Development of a TGFβ-IL-2/15 Switch Receptor for Use in Adoptive Cell Therapy.Biomedicines · 2023
   Article
8. Small immunological clocks identified by deep learning and gradient boosting.Frontiers in immunology · 2023
   Article
9. Targeting tissue-resident memory CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2022
   Article
10. Interleukin 15 in Cell-Based Cancer Immunotherapy.International journal of molecular sciences · 2022
    Review
11. Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection.Viruses · 2021
    Review
12. Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction.International journal of molecular sciences · 2019
    Review
13. CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.The Journal of clinical investigation · 2018
    Article
14. Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion.Journal of immunology (Baltimore, Md. : 1950) · 2018
    Article
15. Loss of JAK1 Drives Innate Immune Deficiency.Frontiers in immunology · 2018
    Article
16. Frontline Science: Functionally impaired geriatric CAR-T cells rescued by increased α5β1 integrin expression.Journal of leukocyte biology · 2017
    Article
17. Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.Beneficial microbes · 2017
    Article
18. Immunological characterization of the early human fracture hematoma.Immunologic research · 2016
    Article
19. IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice.Molecular medicine reports · 2015
    Article
20. Concise review: engineering the fusion of cytokines for the modulation of immune cellular responses in cancer and autoimmune disorders.Stem cells translational medicine · 2015
    Review

Corrections and comments

• Comment on
  Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.2012

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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