ArticleJournal of lipid research2013
CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- Differences in Pigment Content and Expression of Cocoon Color Formation-Related Genes in Multiple Silkworm Strains.Insects · 2026Article
- Old European Silkworm Breeds Reared in Early-20th-Century Bulgaria and Their Potential Use in Modern Sericulture.Insects · 2025Review
- Role Analysis of theAnimals : an open access journal from MDPI · 2025Article
- The roles of a MiRNA and its targeted methyltransferase 3 in carotenoid accumulation in adductor muscles of QN orange scallops.BMC genomics · 2025Article
- Article
- Egg Cooling After Oviposition Extends the Permissive Period for Microinjection-Mediated Genome Modification inInternational journal of molecular sciences · 2024Article
- Antioxidant and cholesterol regulatory effect of flavonoid-rich silk sericin.Food science and biotechnology · 2024Article
- The Potential of Natural Carotenoids-Containing Sericin of the Domestic SilkwormInternational journal of molecular sciences · 2024Article
- Pigment Identification and Gene Expression Analysis during Erythrophore Development in Spotted Scat (International journal of molecular sciences · 2023Article
- The genetic basis of conspicuous coloration in the Guadeloupean anole: Evolution by sexual and ecological selection.Ecology and evolution · 2023Article
- Effects of Natural and Synthetic Astaxanthin on Growth, Body Color, and Transcriptome and Metabolome Profiles in the Leopard Coralgrouper (Animals : an open access journal from MDPI · 2023Article
- Deciphering the Genetic Basis of Silkworm Cocoon Colors Provides New Insights into Biological Coloration and Phenotypic Diversification.Molecular biology and evolution · 2023Article
- High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation.Nature communications · 2022Article
- Genetic architecture underlying changes in carotenoid accumulation during the evolution of the blind Mexican cavefish, Astyanax mexicanus.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Carotenoid metabolism at the intestinal barrier.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Sterol Characteristics in Silkworm Brain and Various Tissues Characterized by Precise Sterol Profiling Using LC-MS/MS.International journal of molecular sciences · 2019Article
- The Effect of Strain and Rearing Medium on the Chemical Composition, Fatty Acid Profile and Carotenoid Content in Silkworm (Animals : an open access journal from MDPI · 2019Article
- Deficiency of a pyrroline-5-carboxylate reductase produces the yellowish green cocoon 'Ryokuken' of the silkworm, Bombyx mori.Heredity · 2018Article
- SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux.Annual review of physiology · 2018Review
- Admixture mapping in a hybrid zone reveals loci associated with avian feather coloration.Proceedings. Biological sciences · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary carotenoids are absorbed in the intestine and delivered to various tissues by circulating lipoproteins; however, the mechanism underlying selective delivery of different carotenoid species to individual tissues remains elusive. The products of the Yellow cocoon (C) gene and the Flesh (F) gene of the silkworm Bombyx mori determine the selectivity for transport of lutein and β-carotene, respectively, to the silk gland. We previously showed that the C gene encodes Cameo2, a CD36 family member, which is thought to function as a transmembrane lipoprotein receptor. Here, we elucidated the molecular identity of the F gene product by positional cloning, as SCRB15, a paralog of Cameo2 with 26% amino acid identity. In the F mutant, SCRB15 mRNA structure was severely disrupted, due to a 1.4 kb genomic insertion in a coding exon. Transgenic expression of SCRB15 in the middle silk gland using the binary GAL4-UAS expression system enhanced selective β-carotene uptake by the middle silk gland, while transgenic expression of Cameo2 enhanced selective lutein uptake under the same GAL4 driver. Our findings indicate that divergence of genes in the CD36 family determines the selectivity of carotenoid species uptake by silk gland tissue and that CD36-homologous proteins can discriminate among carotenoid species.
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