ArticleMolecules (Basel, Switzerland)2012
Amelioration of dextran sodium sulfate-induced colitis in mice by Rhodobacter sphaeroides extract.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Regulatory effects ofInternational journal of medical sciences · 2021Trial
- Applications of Probiotic Constituents in Cosmetics.Molecules (Basel, Switzerland) · 2023Review
- Dietary Inclusion of Seabuckthorn (Frontiers in physiology · 2022Article
- Sinomenine Hydrochloride Ameliorates Fish Foodborne EnteritisFrontiers in immunology · 2021Article
- Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways.World journal of gastroenterology · 2020Review
- Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment.Nature communications · 2019Article
- Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats.International journal of molecular sciences · 2018Article
- Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity.Frontiers in microbiology · 2017Article
- Extract from a mutant Rhodobacter sphaeroides as an enriched carotenoid source.Food & nutrition research · 2016Article
- Skin microbiota of first cousins affected by psoriasis and atopic dermatitis.Clinical and molecular allergy : CMA · 2016Article
- Gelatin tannate ameliorates acute colitis in mice by reinforcing mucus layer and modulating gut microbiota composition: Emerging role for 'gut barrier protectors' in IBD?United European gastroenterology journal · 2014Article
- Chronic exposure to Rhodobacter sphaeroides extract Lycogen™ prevents UVA-induced malondialdehyde accumulation and procollagen I down-regulation in human dermal fibroblasts.International journal of molecular sciences · 2014Article
- An extract of Rhodobacter sphaeroides reduces cisplatin-induced nephrotoxicity in mice.Toxins · 2013Article
- The extract of Rhodobacter sphaeroides inhibits melanogenesis through the MEK/ERK signaling pathway.Marine drugs · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria can produce some compounds in response to their environment. These compounds are widely used in cosmetic and pharmaceutical applications. Some probiotics have immunomodulatory activities and modulate the symptoms of several diseases. Autoimmune diseases represent a complex group of conditions that are thought to be mediated through the development of autoreactive immunoresponses. Inflammatory bowel disease (IBD) is common autoimmune disease that affects many individuals worldwide. Previously, we found that the extracts of Rhodobacter sphaeroides (Lycogen) inhibited nitric oxide production and inducible nitric-oxide synthase expression in activated macrophages. In this study, the effect of Lycogen, a potent anti-inflammatory agent, was evaluated in mice with dextran sodium sulfate (DSS)-induced colitis. Oral administration of Lycogen reduced the expressions of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) in female BABL/c mice. In addition, the increased number of bacterial flora in the colon induced by DSS was amelirated by Lycogen. The histological score of intestinal inflammation in 5% DSS-treated mice after oral administration of Lycogen was lower than that of control mice. Meanwhile, Lycogen dramatically prolonged the survival of mice with severe colitis. These findings identified that Lycogen is an anti-inflammatory agent with the capacity to ameliorate DSS-induced colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.