ArticleCell cycle (Georgetown, Tex.)2012
Presence of a defect in karyokinesis during megakaryocyte endomitosis.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Modifying platelets at their birth: anti-thrombotic therapy without haemorrhage.Frontiers in pharmacology · 2024Review
- A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals.Journal of cell science · 2022Article
- The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links.Genes · 2020Review
- Kinase signaling and targeted therapy for primary myelofibrosis.Experimental hematology · 2017Review
- Identification of a potent small molecule capable of regulating polyploidization, megakaryocyte maturation, and platelet production.Journal of hematology & oncology · 2016Article
- Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.Haematologica · 2016Article
- [Iron deficiency, thrombocytosis and thromboembolism].Wiener medizinische Wochenschrift (1946) · 2016Review
- P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.Oncotarget · 2016Article
- Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors.PloS one · 2016Article
- Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation.Stem cell investigation · 2015Review
- Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.Blood · 2014Article
- Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin.American journal of hematology · 2014Article
- Differential regulation of MCM7 and its intronic miRNA cluster miR-106b-25 during megakaryopoiesis induced polyploidy.RNA biology · 2014Article
- 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts.Cell cycle (Georgetown, Tex.) · 2014Article
- Role of Rho-GTPases in megakaryopoiesis.Small GTPasesReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Megakaryocyte is the naturally polyploid cell that gives rise to platelets. Polyploidization occurs by endomitosis, a process corresponding to a late failure of cytokinesis with a backward movement of the daughter cells. Generally, a pure defect in cytokinesis produces a multinucleated cell, but megakaryocytes are characterized by a single polylobulated nucleus with a 2 (N) ploidy. Here, we show the existence of a defect in karyokinesis during the endomitotic process. From late telophase until the reversal of cytokinesis, some dipolar mitosis/endomitosis and most multipolar endomitosis present a thin DNA link between the segregated chromosomes surrounded by an incomplete nuclear membrane formation, which implies that sister chromatid separation is not complete. This observation may explain why polyploid megakaryocytes display a single polylobulated nucleus along with an increase in ploidy.
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