ArticleDevelopmental biology2013
The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Ecdysone receptor autonomously controls germ cell differentiation in the Drosophila ovary.Development (Cambridge, England) · 2026Article
- Article
- Article
- Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis.Nature communications · 2025Article
- Functional Study of PTSMAD4 in the Spermatogenesis of the Swimming CrabInternational journal of molecular sciences · 2024Article
- RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis.Science China. Life sciences · 2024Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024Article
- Review
- A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis.Cell death & disease · 2022Article
- α-Tubulin Regulates the Fate of Germline Stem Cells in Drosophila Testis.Scientific reports · 2021Article
- Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.Developmental biology · 2021Review
- Lola regulateseLife · 2020Article
- Identifying Genome-Wide Sequence Variations and Candidate Genes Implicated in Self-Incompatibility by ResequencingInternational journal of molecular sciences · 2019Article
- Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit.Nature communications · 2019Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Evidence for a hierarchical transcriptional circuit in Drosophila male germline involving testis-specific TAF and two gene-specific transcription factors, Mod and Acj6.FEBS letters · 2018Article
- Bactrocera dorsalis male sterilization by targeted RNA interference of spermatogenesis: empowering sterile insect technique programs.Scientific reports · 2016Article
- cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors.PloS one · 2016Article
- Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during male germ cell differentiation, including the switch from transit amplifying progenitor to spermatocyte growth and differentiation, as well as meiotic cell cycle progression and spermiogenesis. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages.
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