Trial reportEuropean journal of heart failure2013
Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF.
Trial report in European journal of heart failure, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Dyspnea Measurement in Acute Heart Failure: A Systematic Review and Evidence Map of Randomized Controlled Trials.Frontiers in medicine · 2021Pooled it
- Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
- Rationale and Design of the ATHENA-HF Trial: Aldosterone Targeted Neurohormonal Combined With Natriuresis Therapy in Heart Failure.JACC. Heart failure · 2016Trial
- Evaluation of a provocative dyspnea severity score in acute heart failure.American heart journal · 2016Trial
- Recognition of worsening heart failure symptoms, help-seeking attitudes, and time-to-presentation in chronic heart failure: a single-center KAP study in China.Frontiers in cardiovascular medicine · 2026Article
- Remote Dielectric Sensing Technology in Heart Failure: Correlating Lung-Fluid Volume Shifts with Postural Changes and Dyspnea Severity.CJC open · 2025Article
- Lack of correlation between different congestion markers in acute decompensated heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Early use of remote dielectric sensing after hospitalization to reduce heart failure readmissions.ESC heart failure · 2021Article
- Patterns of dyspnoea onset in patients with acute heart failure: clinical and prognostic implications.ESC heart failure · 2019Article
- Relationship Between Enrolling Country Income Level and Patient Profile, Protocol Completion, and Trial End Points.Circulation. Cardiovascular quality and outcomes · 2018Observational
- Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure: Insights From ASCEND-HF Trial.JACC. Heart failure · 2018Article
- Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).Journal of the American Heart Association · 2018Article
- The clinical course of health status and association with outcomes in patients hospitalized for heart failure: insights from ASCEND-HF.European journal of heart failure · 2016Article
- Mineralocorticoid Receptor Antagonism in Acute Heart Failure.Current treatment options in cardiovascular medicine · 2015Article
- Relation of dyspnea severity on admission for acute heart failure with outcomes and costs.The American journal of cardiology · 2015Article
- Treatment Approaches to Congestion Relief in Acute Decompensated HF: Insights After DOSE-AHF and CARRESS-HF.Current treatment options in cardiovascular medicine · 2014Article
- Assessment of dyspnea early in acute heart failure: patient characteristics and response differences between likert and visual analog scales.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2014Article
- Incorporating common biomarkers into the clinical management of heart failure.Current heart failure reports · 2013Review
- Learning from recent trials and shaping the future of acute heart failure trials.American heart journal · 2013Review
- Testing of a health-related quality of life model in patients with heart failure: A cross-sectional, correlational study.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes. METHODS AND
resultsASCEND-HF was a randomized trial of nesiritide vs. placebo in 7141 patients hospitalized with acute HF in which dyspnoea relief at 6 h was measured on a 7-point Likert scale. Patients were classified as having early dyspnoea relief if they experienced moderate or marked dyspnoea improvement at 6 h. We analysed the clinical characteristics, geographical variation, and outcomes (mortality, mortality/HF hospitalization, and mortality/hospitalization at 30 days) associated with early dyspnoea relief. Early dyspnoea relief occurred in 2984 patients (43%). In multivariable analyses, predictors of dyspnoea relief included older age and oedema on chest radiograph; higher systolic blood pressure, respiratory rate, and natriuretic peptide level; and lower serum blood urea nitrogen (BUN), sodium, and haemoglobin (model mean C index = 0.590). Dyspnoea relief varied markedly across countries, with patients enrolled from Central Europe having the lowest risk-adjusted likelihood of improvement. Early dyspnoea relief was associated with lower risk-adjusted 30-day mortality/HF hospitalization [hazard ratio (HR) 0.81; 95% confidence interval (CI) 0.68-0.96] and mortality/hospitalization (HR 0.85; 95% CI 0.74-0.99), but similar mortality.
conclusionClinical characteristics such as respiratory rate, pulmonary oedema, renal function, and natriuretic peptide levels are associated with early dyspnoea relief, and moderate or marked improvement in dyspnoea was associated with a lower risk for 30-day outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.