ArticleBone2013
Clinical risk factors, bone density and fall history in the prediction of incident fracture among men and women.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- The effect of non-pharmacological interventions on bone health among patients with low bone mass: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Parkinson's disease and risk of fracture: a meta-analysis of prospective cohort studies.PloS one · 2014Pooled it
- Functional benefits are sustained after a program of supervised resistance exercise in cancer patients with bone metastases: longitudinal results of a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Trial
- Laxative use and incident falls, fractures and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative.BMC geriatrics · 2013Trial
- Social vulnerability index enhances FRAX prediction of hip fractures in fall patients.Scientific reports · 2025Article
- Short-term effect of sunshine duration on daily emergency visits for hip fractures in Beijing, China: a time-series study.Archives of osteoporosis · 2025Article
- Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management.International journal of molecular sciences · 2024Review
- Fracture risk prediction in old Chinese people-a narrative review.Archives of osteoporosis · 2023Review
- Article
- The Influence of Fall Direction and Hip Protector on Fracture Risk: FE Model Predictions Driven by Experimental Data.Annals of biomedical engineering · 2022Article
- Article
- Incidence and risk factors for osteoporotic non-vertebral fracture in low-income community-dwelling elderly: a population-based prospective cohort study in Brazil. The São Paulo Ageing and Health (SPAH) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Sex-Specific Difference in Dynamic Balance Following Total Hip Replacement.Innovation in aging · 2021Article
- T Scores, FRAX, Frailty Phenotype, Falls, and Its Relationship to Fractures in Patients on Maintenance Hemodialysis.Canadian journal of kidney health and disease · 2021Article
- Inclusion of medication-related fall risk in fall risk assessment tool in geriatric care units.BMC geriatrics · 2020Article
- Understanding Osteoporosis Screening Practices in Men: A Nationwide Physician Survey.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2020Article
- Review
- Depression, falls, and fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- A fall in the previous 12 months predicts fracture in the subsequent 5 years in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Screening for high hip fracture risk does not impact on falls risk: a post hoc analysis from the SCOOP study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The FRAX(tr) algorithm uses clinical risk factors (CRF) and bone mineral density (BMD) to predict fracture risk but does not include falls history in the calculation. Using results from the Hertfordshire Cohort Study, we examined the relative contributions of CRFs, BMD and falls history to fracture prediction. We studied 2299 participants at a baseline clinic that included completion of a health questionnaire and anthropometric data. A mean of 5.5years later (range 2.9-8.8years) subjects completed a postal questionnaire detailing fall and fracture history. In a subset of 368 men and 407 women, bone densitometry was performed using a Hologic QDR 4500 instrument. There was a significantly increased risk of fracture in men and women with a previous fracture. A one standard deviation drop in femoral neck BMD was associated with a hazards ratio (HR) of incident fracture (adjusted for CRFs) of 1.92 (1.04-3.54) and 1.77 (1.16-2.71) in men and women respectively. A history of any fall since the age of 45years resulted in an unadjusted HR of fracture of 7.31 (3.78-14.14) and 8.56 (4.85-15.13) in men and women respectively. In a ROC curve analysis, the predictive capacity progressively increased as BMD and previous falls were added into an initial model using CRFs alone. Falls history is a further independent risk factor for fracture. Falls risk should be taken into consideration when assessing whether or not to commence medication for osteoporosis and should also alert the physician to the opportunity to target falls risk directly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.