ArticleJournal of critical care2013
Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study.
Article in Journal of critical care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.Kidney international · 2020 · on this mapGuideline
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Urinary electrolyte parameters in sepsis-associated acute kidney injury: A prospective observational study.Indian journal of anaesthesia · 2025Article
- Incidence of acute kidney injury and its predictors among neonates admitted at neonatal intensive care unit of, Northwest Ethiopia comprehensive specialized hospitals, 2023.BMC pediatrics · 2024Article
- Urinary albumin-to-creatinine ratio and serum albumin are predictors of acute kidney injury in non-ventilated COVID-19 patients: a single-center prospective cohort study.International urology and nephrology · 2023Article
- Biological variation in the serum and urine kidney injury markers of a healthy population measured within 24 hours.BMC nephrology · 2022Article
- Urine biochemistry assessment in the sequential evaluation of renal function: Time to think outside the box.Frontiers in medicine · 2022Article
- Acute Kidney Injury in the Intensive Care Unit: The Most Reliable Way to Predict the Future is to Create It.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- The need for disruptive innovation in acute kidney injury.Clinical and experimental nephrology · 2020Review
- Relationship between platelet/lymphocyte ratio and prognosis of patients with septic acute kidney injury: A pilot study.Journal of the Chinese Medical Association : JCMA · 2020Article
- Nephroprotective Effect ofBiomolecules · 2020Article
- Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study.Critical care (London, England) · 2020Article
- Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery.Critical care (London, England) · 2020Article
- Quick Recovery of Renal Alterations and Inflammatory Activation after a Marathon.Kidney diseases (Basel, Switzerland) · 2019Article
- Global epidemiology and outcomes of acute kidney injury.Nature reviews. Nephrology · 2018Review
- Fractional excretion of electrolytes in volume-responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications.Journal of veterinary internal medicine · 2018Observational
- Predicting acute kidney injury: current status and future challenges.Journal of nephrology · 2018Review
- The Japanese Clinical Practice Guideline for acute kidney injury 2016.Journal of intensive care · 2018Article
- Urinary Biochemistry in the Diagnosis of Acute Kidney Injury.Disease markers · 2018Review
- Acute Kidney Injury Recognition in Low- and Middle-Income Countries.Kidney international reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeDetermine whether there are unique patterns to the urine biochemistry profile in septic compared with non-septic acute kidney injury (AKI) and whether urinary biochemistry predicts worsening AKI, need for renal replacement therapy and mortality. MATERIALS AND
methodsProspective cohort study of critically ill patients with septic and non-septic AKI, defined by the RIFLE (Risk, Injury, Failure, Loss, End-Stage) criteria. Urine biochemistry parameters were compared between septic and non-septic AKI and were correlated with neutrophil gelatinase-associated lipocalin (NGAL), worsening AKI, renal replacement therapy (RRT), and mortality.
resultsEighty-three patients were enrolled, 43 (51.8%) with sepsis. RIFLE class was not different between groups (P = .43). Urine sodium (UNa) <20 mmol/L, fractional excretion of sodium (FeNa) <1%, and fractional excretion of urea (FeU) <35% were observed in 25.3%, 57.8%, and 33.7%, respectively. Septic AKI had lower UNa compared with non-septic AKI (P = .04). There were no differences in FeNa or FeU between groups. Urine NGAL was higher for FeNa ≥ 1% compared to FeNa<1% (177.4 ng/mL [31.9-956.5] vs 48.0 ng/mL [21.1-232.4], P = .04). FeNa showed low correlation with urine NGAL (P = .05) and plasma NGAL (P = .14). There was poor correlation between FeU and urine NGAL (P = .70) or plasma NGAL (P = .41). UNa, FeNa, and FeU showed poor discrimination for worsening AKI, RRT and mortality.
conclusionUrine biochemical profiles do not discriminate septic and non-septic AKI. UNa, FeNa, and FeU do not reliably predict biomarker release, worsening AKI, RRT or mortality. These data imply limited utility for these measures in clinical practice in critically ill patients with AKI.
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