ArticlePsychoneuroendocrinology2013
Neonatal amygdala lesions alter basal cortisol levels in infant rhesus monkeys.
Article in Psychoneuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis.Progress in neurobiology · 2015Pooled it
- Hair and plasma cortisol throughout the first 3 years of development in infant rhesus macaques, Macaca mulatta.Developmental psychobiology · 2023Article
- Quantification of early gait development: Expanding the application of Catwalk technology to an infant rhesus macaque model.Journal of neuroscience methods · 2023Article
- The developmental consequences of early adverse care on infant macaques: A cross-fostering study.Psychoneuroendocrinology · 2022Article
- Prenatal PMEnvironmental research · 2022Article
- Prenatal metal mixtures and sex-specific infant negative affectivity.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Multidimensional processing in the amygdala.Nature reviews. Neuroscience · 2020Review
- The effects of neonatal amygdala or hippocampus lesions on adult social behavior.Behavioural brain research · 2017Article
- Multiple Anesthetic Exposure in Infant Monkeys Alters Emotional Reactivity to an Acute Stressor.Anesthesiology · 2015Article
- Adult social behavior with familiar partners following neonatal amygdala or hippocampus damage.Behavioral neuroscience · 2015Article
- Social buffering of stress responses in nonhuman primates: Maternal regulation of the development of emotional regulatory brain circuits.Social neuroscience · 2015Review
- Neonatal amygdala lesions advance pubertal timing in female rhesus macaques.Psychoneuroendocrinology · 2015Article
- Neonatal Perirhinal Lesions in Rhesus Macaques Alter Performance on Working Memory Tasks with High Proactive Interference.Frontiers in systems neuroscience · 2015Article
- Neonatal amygdala lesions alter mother-infant interactions in rhesus monkeys living in a species-typical social environment.Developmental psychobiology · 2014Article
- Mother recognition and preference after neonatal amygdala lesions in rhesus macaques (Macaca mulatta) raised in a semi-naturalistic environment.Developmental psychobiology · 2014Article
- Neonatal amygdala lesions lead to increased activity of brain CRF systems and hypothalamic-pituitary-adrenal axis of juvenile rhesus monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Sex-dependent role of the amygdala in the development of emotional and neuroendocrine reactivity to threatening stimuli in infant and juvenile rhesus monkeys.Hormones and behavior · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The amygdala is mostly thought to exert an excitatory influence on the hypothalamic-pituitary-adrenal (HPA) axis, although its role regulating HPA basal tone is less clear, particularly during primate development. The current study examined the effects of neonatal amygdala lesions on basal HPA function and the postnatal testosterone (T) surge of rhesus monkeys reared with their mothers in large outdoor social groups. An early morning basal blood sample was collected at 2.5 months of age, whereas at 5 months samples were collected not only at sunrise, but also at mid-day and sunset to examine the diurnal rhythm of cortisol. At 2.5 months of age sham-operated males exhibited higher cortisol than females, but this sex difference was abolished by neonatal amygdalectomy, with lesioned males also showing lower basal cortisol than controls. Although neonatal amygdalectomy did not alter the postnatal T surge, there was a positive relationship between T and basal cortisol levels. At 5 months of age, neither the sex difference in cortisol, nor its correlation with T levels were apparent any longer. Instead, the diurnal cortisol rhythm of both males and females with amygdalectomy showed a blunted decline from mid-day to sunset compared to controls. These results indicate that neonatal amygdala damage alters basal HPA function in infant rhesus monkeys, affecting males only at early ages (at 2.5 months), while leaving the postnatal T surge intact, and resulting in a flattened diurnal rhythm in both genders at the later ages. Thus, the primate amygdala has a critical influence on the HPA axis in the first few months of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.