ArticleMolecular autism2012
Comparing biobehavioral profiles across two social stress paradigms in children with and without autism spectrum disorders.
Article in Molecular autism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Who cites it
47 citing papers in PubMed, 86 citations in OpenAlex.
- A huggable device can reduce the stress of calling an unfamiliar person on the phone for individuals with ASD.PloS one · 2021Trial
- Pain Expectation in Individuals With High Autistic Traits: Decision-Evaluation Processes and Oxytocin Modulation.Annals of the New York Academy of Sciences · 2026Article
- A Comprehensive Investigation of Social Anxiety and Social Evaluative Stress in Autistic Children and Adolescents and Specific Learning Disorders.Journal of autism and developmental disorders · 2026Article
- Article
- Core Deficits and Eating Behaviors in Children with Autism: The Role of Executive Function.Nutrients · 2025Article
- The intersection and developmental trajectory of morning cortisol and testosterone in autistic and neurotypical youth.Molecular autism · 2025Article
- Social Context in Stress and Autism: Comparing Physiological Profiles Across Two Social Paradigms in Youth with and without Autism Spectrum Disorder.Research in autism spectrum disorders · 2024Article
- The developmental trajectory of diurnal cortisol in autistic and neurotypical youth.Development and psychopathology · 2023Article
- Social and executive functioning in individuals with autism spectrum disorder without intellectual disability: The case-control study protocol of the CNeSA study.Frontiers in child and adolescent psychiatry · 2023Article
- REAC Noninvasive Neurobiological Stimulation in Autism Spectrum Disorder for Alleviating Stress Impact.Advances in neurodevelopmental disorders · 2023Article
- Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth.Autism research : official journal of the International Society for Autism Research · 2022Article
- Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Autistic-Like Behaviors of SHANK3 Mutant Beagle Dogs.Stem cells translational medicine · 2022Article
- Article
- The impact of COVID-19 on stress, anxiety, and coping in youth with and without autism and their parents.Autism research : official journal of the International Society for Autism Research · 2021Article
- A Comparison of the Stress Survey Schedule in Children with Autism and Typically Developing Children: A Brief Report.Journal of autism and developmental disorders · 2021Article
- Developmental effects in physiological stress in early adolescents with and without autism spectrum disorder.Psychoneuroendocrinology · 2021Article
- Oxytocin and cortisol concentrations in adults with and without autism spectrum disorder in response to physical exercise.Comprehensive psychoneuroendocrinology · 2021Article
- Stress System Activation in Children and Adolescents With Autism Spectrum Disorder.Frontiers in neuroscience · 2021Review
- Peer Actors and Theater Techniques Play Pivotal Roles in Improving Social Play and Anxiety for Children With Autism.Frontiers in psychology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelled
backgroundAutism spectrum disorders (ASD) are defined by impairment in reciprocal social interaction and flexible adaptation to the environment. This study compared physiological stress in children with and without ASD exposed to two social stress protocols. We hypothesized that the ASD group would show heightened initial and enduring cortisol levels to the social stressors, which would be moderated by age and intelligence.
methodsTwenty-seven children with ASD and 32 with typical development (TYP) completed a standardized social-evaluative performance task and a validated paradigm of social play with peers. Physiological stress was measured by salivary cortisol at nine time points. Statistical approaches included repeated-measures linear mixed models and correlation analyses.
resultsThe average cortisol level of both groups during initial exposure to social situations was significantly greater than baseline levels (ASD, P = 0.018; TYP, P = 0.006). Stress responsivity was significantly different between the groups; the TYP group showed a significant reduction in cortisol over time (P = 0.023), whereas the ASD group maintained an elevated cortisol level (P >0.05). The ASD group evidenced greater variability in between-group, within-group and intra-individual analyses. Age was a positive moderator of stress for the ASD group (P = 0.047), whereas IQ was a negative moderator for the TYP group (P = 0.061).
conclusionsInitial stress to novel social scenarios is idiosyncratic and predictive of subsequent exposure. Amidst significant variability in cortisol, children with ASD show enhanced and sustained social stress that increases with age. Developmental and cognitive factors differentially moderate stress in children with ASD and TYP, respectively. A model of neuroendocrine reactivity is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.