ArticleNeurobiology of aging2013
Spatial behavior and seizure-induced changes in c-fos mRNA expression in young and old rats.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review.Current pharmaceutical biotechnology · 2024Pooled it
- Growth hormone is required for hippocampal engram cell maturation.Science advances · 2025Article
- Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief.Hormones and behavior · 2025Review
- Clinico-genetic Analysis of Adenosine Signaling Pathway in Drug-Resistant Epilepsy.Annals of Indian Academy of Neurology · 2025Article
- Delayed formation of neural representations of space in aged mice.Aging cell · 2023Article
- Effect of repeated seizures on spatial exploration and immediate early gene expression in the hippocampus and dentate gyrus.IBRO neuroscience reports · 2022Article
- Understanding the physical basis of memory: Molecular mechanisms of the engram.The Journal of biological chemistry · 2022Review
- Behavioral and Cellular Tagging in Young and in Early Cognitive Aging.Frontiers in aging neuroscience · 2022Article
- Neuronal ensemble-specific DNA methylation strengthens engram stability.Nature communications · 2020Article
- Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Psychometric Properties of the Persian Version of the Quality of Life in Epilepsy Inventory in the Later Life.Journal of epilepsy research · 2016Article
- Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.Hippocampus · 2016Article
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The subcellular processes of gene induction and expression in the hippocampus are likely to underlie some of the known age-related impairments in spatial learning and memory. It is well established that immediate-early genes are rapidly and transiently induced in response to neuronal activity and this expression is required for stabilization of durable memories. To examine whether age-related memory impairment might be caused, in part, by differences in the level of cellular activation or subcellular processing, c-fos expression in CA1 pyramidal and dentate gyrus granule cells in the dorsal hippocampus of young and old rats was determined using fluorescence in situ hybridization and reverse transcription polymerase chain reaction. No significant age differences were found in the numbers of pyramidal or granule cells that show c-fos expression; however, c-fos mRNA transcripts were altered in these 2 cell types in aged animals. These findings suggest that though the networks of cells that participate in behavior or seizure-induced activity are largely maintained in aged rats, their RNA transcript levels are altered. This might, in part, contribute to cognitive deficits frequently observed with advancing age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.