ArticleGenome biology2012
The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 54 citations in OpenAlex.
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- Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi.Microbial genomics · 2024Article
- Long-term evolution of Streptococcus mitis and Streptococcus pneumoniae leads to higher genetic diversity within rather than between human populations.PLoS genetics · 2024Article
- The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci.PLoS pathogens · 2022Article
- Targeted control of pneumolysin production by a mobile genetic element inMicrobial genomics · 2022Article
- Article
- Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates.Microbial genomics · 2020Article
- Genomic Insight into the Spread of Meropenem-Resistant Streptococcus pneumoniae SpainEmerging infectious diseases · 2020Article
- Two multi-fragment recombination events resulted in the β-lactam-resistant serotype 11A-ST6521 related to Spain9V-ST156 pneumococcal clone spreading in south-western Europe, 2008 to 2016.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Genomic epidemiology of penicillin-non-susceptibleMicrobial genomics · 2019Review
- Competence inFrontiers in cellular and infection microbiology · 2019Review
- Function of BriC peptide in the pneumococcal competence and virulence portfolio.PLoS pathogens · 2018Article
- The evolution of antibiotic resistance in a structured host population.Journal of the Royal Society, Interface · 2018Article
- Evolution via recombination: Cell-to-cell contact facilitates larger recombination events in Streptococcus pneumoniae.PLoS genetics · 2018Article
- A Population-Based Descriptive Atlas of Invasive Pneumococcal Strains Recovered Within the U.S. During 2015-2016.Frontiers in microbiology · 2018Article
- Puzzling Over the Pneumococcal Pangenome.Frontiers in microbiology · 2018Review
- Diversity of MosaicAntimicrobial agents and chemotherapy · 2017Article
- An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application toProceedings. Biological sciences · 2017Article
- Promiscuous signaling by a regulatory system unique to the pandemic PMEN1 pneumococcal lineage.PLoS pathogens · 2017Article
- Pneumococcal prophages are diverse, but not without structure or history.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStreptococcus pneumoniae, also called the pneumococcus, is a major bacterial pathogen. Since its introduction in the 1940s, penicillin has been the primary treatment for pneumococcal diseases. Penicillin resistance rapidly increased among pneumococci over the past 30 years, and one particular multidrug-resistant clone, PMEN1, became highly prevalent globally. We studied a collection of 426 pneumococci isolated between 1937 and 2007 to better understand the evolution of penicillin resistance within this species.
resultsWe discovered that one of the earliest known penicillin-nonsusceptible pneumococci, recovered in 1967 from Australia, was the likely ancestor of PMEN1, since approximately 95% of coding sequences identified within its genome were highly similar to those of PMEN1. The regions of the PMEN1 genome that differed from the ancestor contained genes associated with antibiotic resistance, transmission and virulence. We also revealed that PMEN1 was uniquely promiscuous with its DNA, donating penicillin-resistance genes and sometimes many other genes associated with antibiotic resistance, virulence and cell adherence to many genotypically diverse pneumococci. In particular, we describe two strains in which up to 10% of the PMEN1 genome was acquired in multiple fragments, some as long as 32 kb, distributed around the recipient genomes. This type of directional genetic promiscuity from a single clone to numerous unrelated clones has, to our knowledge, never before been described.
conclusionsThese findings suggest that PMEN1 is a paradigm of genetic success both through its epidemiology and promiscuity. These findings also challenge the existing views about horizontal gene transfer among pneumococci.
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