Evidence map›Paper›PMID 23158412›Full record

ReviewCurrent problems in cardiology2013

Sex and gender differences in myocarditis and dilated cardiomyopathy.

DeLisa Fairweather, Leslie T Cooper, Lori A Blauwet

Open access · greenAbstract readReview
In one paragraph

Review in Current problems in cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 4 syntheses or guidelines pooled it, 327 citations in OpenAlex.

  1. Pooled it
  2. Brazilian Society of Cardiology Guideline on Myocarditis - 2022.Arquivos brasileiros de cardiologia · 2022
    Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Sex related differences in acute and recurrent pericarditis: A narrative review.American heart journal plus : cardiology research and practice · 2026
    Review
  11. Article
  12. Review
  13. "Bridging the clinical, molecular and genetic perspectives on myocarditis in post-COVID-19 era".International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  14. Article
  15. Health profiles and lifestyles of those with cardiomyopathyThe British journal of cardiology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

DeLisa Fairweather
Leslie T Cooper
Lori A Blauwet
Johns Hopkins University · USMayo Clinic in Arizona · US

Funding

Regulating heart disease: the adjuvant effect of viral infection.R01HL087033 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FAIRWEATHER, DELISA · 2007 to 2011
$2.5M
Sex Differences in Complement during Myocarditis/DCMR01HL111938 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2012 to 2015
$1.6M
Autoimmune Determinants of Human Cardiac MyosinR56HL056267 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI COOPER, LESLIE T, CUNNINGHAM, MADELEINE W. · 2008 to 2015
$933k
NHLBI NIH HHS R01 HL087033NHLBI NIH HHS R01 HL111938NHLBI NIH HHS R56 HL056267
6 · The paper itself

Abstract

Heart failure due to nonischemic dilated cardiomyopathy (DCM) contributes significantly to the global burden of cardiovascular disease. Myocarditis is, in turn, a major cause of acute DCM in both men and women. However, recent clinical and experimental evidence suggests that the pathogenesis and prognosis of DCM differ between the sexes. This seminar provides a contemporary perspective on the immune mediators of myocarditis, including interdependent elements of the innate and adaptive immune response. The heart's acute response to injury is influenced by sex hormones that appear to determine the subsequent risk of chronic DCM. Preliminary data suggest additional genetic variations may account for some of the differences in epidemiology, left ventricular recovery, and survival between men and women. We highlight the gaps in our knowledge regarding the management of women with acute DCM and discuss emerging therapies, including bromocriptine for the treatment of peripartum cardiomyopathy.

Indexed as

Cardiomyopathy, DilatedMyocarditisMyocardiumAnimalsFemaleGenetic Predisposition to DiseaseGonadal Steroid HormonesHealthcare DisparitiesHealth Status DisparitiesHumansInflammation MediatorsMaleRecovery of FunctionRisk FactorsSex FactorsTreatment OutcomeGonadal Steroid HormonesInflammation Mediators

Identifiers

PMID23158412
PMCPMC4136454
OpenAlexW2080629518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.