ArticleThe Journal of surgical research2013
Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis.
Article in The Journal of surgical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence.Frontiers in immunology · 2018Trial
- Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies.Mucosal immunology · 2023Review
- Intestinal alkaline phosphatase modulation by food components: predictive, preventive, and personalized strategies for novel treatment options in chronic kidney disease.The EPMA journal · 2020Review
- Genetics on early onset inflammatory bowel disease: An update.Genes & diseases · 2020Review
- Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy.Scientific reports · 2020Article
- The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study.Scientific reports · 2020Article
- Evaluation of Intestinal Damage Biomarkers in Calves with Atresia Coli.Journal of veterinary research · 2018Article
- The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract.Mediators of inflammation · 2017Review
- Intestinal alkaline phosphatase: a summary of its role in clinical disease.The Journal of surgical research · 2016Review
- Intestinal alkaline phosphatase to treat necrotizing enterocolitis.The Journal of surgical research · 2015Article
- Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain.Infection and immunity · 2015Article
- Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity.World journal of gastroenterology · 2014Review
- The microbiota protects against ischemia/reperfusion-induced intestinal injury through nucleotide-binding oligomerization domain-containing protein 2 (NOD2) signaling.The American journal of pathology · 2014Article
- Intestinal alkaline phosphatase is protective to the preterm rat pup intestine.Journal of pediatric surgery · 2014Article
- Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis.Newborn (Clarksville, Md.)Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNecrotizing enterocolitis (NEC) is the most common surgical emergency in neonates, with an incidence of 0.5-2.4 cases per 1000 live births and a mortality rate between 10% and 50%. Neonates affected by NEC develop a septic injury that is associated with increased risk of neurological impairment due to intraventricular bleeding and chronic lung disease. Intestinal alkaline phosphatase (IAP) is an endogenous protein that has been shown to inactivate the endotoxin lipopolysaccharide (LPS), and has recently been used successfully as an adjunct to treat sepsis in adult patients. We tested the hypothesis that systemic, exogenous IAP will mitigate the inflammatory response as measured by serum levels of proinflammatory cytokines in a rat model of NEC.
methodsNewborn Sprague-Dawley rats were divided into groups. Control pups were dam fed. NEC was induced by feeding formula containing LPS and exposure to intermittent hypoxia. NEC pups were given intraperitoneal injections of 4 or 40 glycine units (U) of IAP or placebo twice daily. Intestine and serum was collected for cytokine analysis as well as measurement of alkaline phosphatase activity.
resultsSystemic IAP administration significantly increased serum alkaline phosphatase activity in a dose- and time-dependent fashion. The proinflammatory cytokines tumor necrosis factor α, interleukin 6, and interleukin 1β were significantly increased in NEC rats versus controls on days 2 and 3. Importantly, treatment with 40 U systemic IAP decreased these proinflammatory cytokines back to near-control levels.
conclusionsSystemic IAP administration appears effective in mitigating the systemic inflammatory response associated with NEC, and may prove to be a valuable adjunctive treatment for NEC.
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