ArticleMultidisciplinary respiratory medicine2012
BMI can influence adult males' and females' airway hyperresponsiveness differently.
Article in Multidisciplinary respiratory medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.International journal of molecular sciences · 2023Review
- The relationship between body mass index and increased airway reactivity based on methacholine challenge test results.Postepy dermatologii i alergologii · 2017Article
- Metabolic origins of childhood asthma.Molecular and cellular pediatrics · 2015Article
- Obesity can influence children's and adolescents' airway hyperresponsiveness differently.Multidisciplinary respiratory medicine · 2013Article
- The asthma phenotype in the obese: distinct or otherwise?Journal of allergy · 2013Article
- Distal airway impairment in obese normoreactive women.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundEpidemiological data indicate that obesity is a risk factor for asthma, but scientific literature is still debating the association between changes in body mass index (BMI) and airway hyperresponsiveness (AHR).
methodsThis study aimed at evaluating the influence of BMI on AHR, in outpatients with symptoms suggestive of asthma.4,217 consecutive adult subjects (2,439 M; mean age: 38.2±14.9 yrs; median FEV1 % predicted: 100 [IQR:91.88-107.97] and FEV1/FVC % predicted: 85.77% [IQR:81.1-90.05]), performed a methacholine challenge test for suspected asthma. Subjects with PD20 < 200 or 200 < PD20 < 800 or PD20 > 800 were considered affected by severe, moderate or mild AHR, respectively.
resultsA total of 2,520 subjects (60% of all cases) had a PD20 < 3,200 μg, with a median PD20 of 366 μg [IQR:168-1010.5]; 759, 997 and 764 patients were affected by mild, moderate and severe AHR, respectively. BMI was not associated with increasing AHR in males. On the contrary, obese females were at risk for AHR only when those with moderate AHR were considered (OR: 1.772 [1.250-2.512], p = 0.001). A significant reduction of FEV1/FVC for unit of BMI increase was found in moderate AHR, both in males (β = -0.255; p =0.023) and in females (β = -0.451; p =0.017).
conclusionsOur findings indicate that obesity influences AHR only in females with a moderate AHR level. This influence may be mediated by obesity-associated changes in baseline lung function.
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Registered trials
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