ArticleJournal of the American Chemical Society2012
Gd(DOTAla): a single amino acid Gd-complex as a modular tool for high relaxivity MR contrast agent development.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Isomerism and Relaxation Properties of Lanthanide(III) Complexes of a Ditopic Ligand with Two DO3A Units Bridged by a Methylene-bis(phosphinate) Spacer.Inorganic chemistry · 2026Article
- Article
- Paramagnetic encoding of molecules.Nature communications · 2022Article
- Complexes of Bifunctional DO3A-N-(α-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies.Molecules (Basel, Switzerland) · 2021Article
- Quantum Dots and GdTopics in current chemistry (Cham) · 2021Review
- Biocompatible iron(II)-doped carbon dots as TMikrochimica acta · 2019Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Optimizing the Relaxivity of MRI Probes at High Magnetic Field Strengths With Binuclear GdFrontiers in chemistry · 2018Article
- Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Intramolecular Hydrogen Bonding Restricts Gd-Aqua-Ligand Dynamics.Angewandte Chemie (International ed. in English) · 2017Article
- Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cancer Theranostic Nanoparticles Self-Assembled from Amphiphilic Small Molecules with Equilibrium Shift-Induced Renal Clearance.Theranostics · 2016Article
- Dendritic Polymers for Theranostics.Theranostics · 2016Review
- Article
- Basic MR relaxation mechanisms and contrast agent design.Journal of magnetic resonance imaging : JMRI · 2015Review
- MR imaging probes: design and applications.Dalton transactions (Cambridge, England : 2003) · 2015Review
- Probing the structure-relaxivity relationship of bis-hydrated Gd(DOTAla) derivatives.Inorganic chemistry · 2015Article
- Hexameric Mn(II) dendrimer as MRI contrast agent.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Article
- A peptide probe for the detection of neurokinin-1 receptor by disaggregation enhanced fluorescence and magnetic resonance signals.Scientific reports · 2014Article
- Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths.The Analyst · 2014Review
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4 authors.
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Abstract
MR imaging at high magnetic fields benefits from an increased signal-to-noise ratio; however T(1)-based MR contrast agents show decreasing relaxivity (r(1)) at higher fields. High field, high relaxivity contrast agents can be designed by carefully controlling the rotational dynamics of the molecule. To this end, we investigated applications of the alanine analogue of Gd(DOTA), Gd(DOTAla). Fmoc-protected DOTAla suitable for solid phase peptide synthesis was synthesized and integrated into polypeptide structures. Gd(III) coordination results in very rigid attachment of the metal chelate to the peptide backbone through both the amino acid side chain and coordination of the amide carbonyl. Linear and cyclic monomers (GdL1, GdC1), dimers (Gd(2)L2, Gd(2)C2), and trimers (Gd(3)L3, Gd(3)C3) were prepared and relaxivities were determined at different field strengths ranging from 0.47 to 11.7 T. Amide carbonyl coordination was indirectly confirmed by determination of the hydration number q for the EuL1 integrated into a peptide backbone, q = 0.96 ± 0.09. The water residency time of GdL1 at 37 °C was optimal for relaxivity, τ(M) = 17 ± 2 ns. Increased molecular size leads to increased per Gd relaxivity (from r(1) = 7.5 for GdL1 to 12.9 mM(-1) s(-1) for Gd(3)L3 at 1.4 T, 37 °C). The cyclic, multimeric derivatives exhibited slightly higher relaxivities than the corresponding linearized multimers (Gd(2)C2: r(1) = 10.5 mM(-1) s(-1) versus Gd(2)C2-red r(1) = 9 mM(-1) s(-1) at 1.4 T, 37 °C). Overall, all six synthesized Gd complexes had higher relaxivities at low, intermediate, and high fields than the clinically used small molecule contrast agent [Gd(HP-DO3A)(H(2)O)].
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