ArticleBMC immunology2012
New perspectives for natural antimicrobial peptides: application as antinflammatory drugs in a murine model.
Article in BMC immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Article
- Antimicrobial Peptides and Their Biomedical Applications: A Review.Antibiotics (Basel, Switzerland) · 2024Review
- Antibiotic Resistant Biofilms and the Quest for Novel Therapeutic Strategies.Indian journal of microbiology · 2024Review
- Review
- Antimicrobial Peptide Synergies for Fighting Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Evaluation of Green-Synthesized Cuprospinel Nanoparticles as a Nanosensor for Detection of Low-Concentration Cd(II) Ion in the Aqueous Solutions by the Quartz Crystal Microbalance Method.Materials (Basel, Switzerland) · 2022Article
- Review
- Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products.Molecules (Basel, Switzerland) · 2021Review
- Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing.Biomolecules · 2021Review
- The Role of Formyl Peptide Receptors in Permanent and Low-Grade Inflammation:International journal of molecular sciences · 2021Review
- Interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection.Scientific reports · 2020Article
- Biomimetic hydroxyapatite nanocrystals are an active carrier forInternational journal of nanomedicine · 2019Article
- QCM-based immunosensor for rapid detection of Salmonella Typhimurium in food.Scientific reports · 2018Article
- Review
- Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro.Scientific reports · 2017Article
- Racing on the Wrong Track.Frontiers in chemistry · 2017Article
- Lactoferrin Adsorbed onto Biomimetic Hydroxyapatite Nanocrystals Controlling - In Vivo - the Helicobacter pylori Infection.PloS one · 2016Article
- Host Antimicrobial Peptides in Bacterial Homeostasis and Pathogenesis of Disease.Antibiotics (Basel, Switzerland) · 2014Article
- Clavanin bacterial sepsis control using a novel methacrylate nanocarrier.International journal of nanomedicine · 2014Article
- Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals.International journal of nanomedicine · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial peptides (AMPs) are an ancient group of defense molecules. AMPs are widely distributed in nature (being present in mammals, birds, amphibians, insects, plants, and microorganisms). They display bactericidal as well as immunomodulatory properties. The aim of this study was to investigate the antimicrobial and anti-inflammatory activities of a combination of two AMPs (temporin B and the royal jellein I) against Staphylococcus epidermidis.
resultsThe temporin B (TB-KK) and the royal jelleins I, II, III chemically modified at the C terminal (RJI-C, RJII-C, RJIII-C), were tested for their activity against 10 different Staphylococcus epidermidis strains, alone and in combination. Of the three royal jelleins, RJI-C showed the highest activity. Moreover, the combination of RJI-C and TB-KK (MIX) displayed synergistic activity. In vitro, the MIX displayed low hemolytic activity, no NO2- production and the ability to curb the synthesis of the pro-inflammatory cytokines TNF-α and IFN-γ to the same extent as acetylsalicylic acid. In vivo, the MIX sterilized mice infected with Staphylococcus epidermidis in eleven days and inhibited the expression of genes encoding the prostaglandin-endoperoxide synthase 2 (COX-2) and CD64, two important parameters of inflammation.
conclusionThe study shows that the MIX - a combination of two naturally occurring peptides - displays both antimicrobial and anti-inflammatory activities.
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