ReviewAntioxidants & redox signaling2013
Proteomic approaches to analyze protein tyrosine nitration.
Review in Antioxidants & redox signaling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Exposure of Apis mellifera (Hymenoptera: Apidae) colonies to imidacloprid impairs larval development, promotes oxidative stress in pupae, and induces changes in the midgut of adult bees.Biological research · 2025Article
- Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration.Biomolecules · 2024Review
- Current Insights on Neurodegeneration by the Italian Proteomics Community.Biomedicines · 2022Review
- Monitoring peptide tyrosine nitration by spectroscopic methods.Amino acids · 2021Article
- Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Review
- Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study.BioMed research international · 2018Article
- Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples.Journal of proteome research · 2017Article
- Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.Circulation research · 2016Review
- Synthetic approaches to protein phosphorylation.Current opinion in chemical biology · 2015Review
- Oxidation as an important factor of protein damage: Implications for Maillard reaction.Journal of biosciences · 2015Review
- Proteomic approaches for the study of tissue specific effects of 3,5,3'-triiodo-L-thyronine and 3,5-diiodo-L-thyronine in conditions of altered energy metabolism.Frontiers in physiology · 2014Review
- iNitro-Tyr: prediction of nitrotyrosine sites in proteins with general pseudo amino acid composition.PloS one · 2014Article
- Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.Molecular & cellular proteomics : MCP · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
significanceThe conversion of protein-bound Tyr residues to 3-nitrotyrosine (3NY) can occur during nitrative stress and has been correlated to aging and many disease states. Proteomic analysis of this post-translational modification, using mass spectrometry-based techniques, is crucial for understanding its potential role in pathological and physiological processes. RECENT ADVANCES: To overcome some of the disadvantages inherent to well-established nitroproteomic methods using anti-3NY antibodies and gel-based separations, methods involving multidimensional chromatography, precursor ion scanning, and/or chemical derivatization have emerged for both identification and quantitation of protein nitration sites. A few of these methods have successfully detected endogenous 3NY modifications from biological samples. CRITICAL ISSUES: While model systems often show promising results, identification of endogenous 3NY modifications remains largely elusive. The frequently low abundance of nitrated proteins in vivo, even under inflammatory conditions, is especially challenging, and sample loss due to derivatization and cleaning may become significant. FUTURE DIRECTIONS: Continued efforts to avoid interference from non-nitrated peptides without sacrificing recovery of nitrated peptides are needed. Quantitative methods are emerging and are crucial for identifying endogenous modifications that may have significant biological impacts.
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