ArticlePloS one2012
Survival of Staphylococcus aureus ST398 in the human nose after artificial inoculation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Marine prebiotics mediate decolonization of Pseudomonas aeruginosa from gut by inhibiting secreted virulence factor interactions with mucins and enriching Bacteroides population.Journal of biomedical science · 2023Article
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- Dehydration Tolerance in Epidemic versus Nonepidemic MRSA Demonstrated by Isothermal Microcalorimetry.Microbiology spectrum · 2022Article
- Real time monitoring of Staphylococcus aureus biofilm sensitivity towards antibiotics with isothermal microcalorimetry.PloS one · 2022Article
- Challenges for Clinical Development of Vaccines for Prevention of Hospital-Acquired Bacterial Infections.Frontiers in immunology · 2020Review
- An experimental Staphylococcus aureus carriage and decolonization model in rhesus macaques (Macaca mulatta).PloS one · 2018Article
- What Is the Origin of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Isolates from Humans without Livestock Contact? An Epidemiological and Genetic Analysis.Journal of clinical microbiology · 2015Article
- Article
- Human Infections with Staphylococcus aureus CC398.Current environmental health reports · 2015Review
- Article
- Impact of livestock-associated MRSA in a hospital setting.Antimicrobial resistance and infection control · 2015Article
- Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo.Genome biology and evolution · 2014Article
- Methicillin-sensitive Staphylococcus aureus CC398 in intensive care unit, France.Emerging infectious diseases · 2014Article
- Livestock-associated MRSA carriage in patients without direct contact with livestock.PloS one · 2014Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence that MRSA ST398 of animal origin is only capable of temporarily occupying the human nose, and it is therefore, often considered a poor human colonizer.We inoculated 16 healthy human volunteers with a mixture of the human MSSA strain 1036 (ST931, CC8) and the bovine MSSA strain 5062 (ST398, CC398), 7 weeks after a treatment with mupirocin and chlorhexidine-containing soap. Bacterial survival was studied by follow-up cultures over 21 days. The human strain 1036 was eliminated faster (median 14 days; range 2-21 days) than the bovine strain 5062 (median 21 days; range 7-21 days) but this difference was not significant (p = 0.065). The bacterial loads were significantly higher for the bovine strain on day 7 and day 21. 4/14 volunteers (28.6%) showed elimination of both strains within 21 days. Of the 10 remaining volunteers, 5 showed no differences in bacterial counts between both strains, and in the other 5 the ST398 strain far outnumbered the human S. aureus strain. Within the 21 days of follow-up, neither human strain 1036 nor bovine strain 5062 appeared to acquire or lose any mobile genetic elements. In conclusion, S. aureus ST398 strain 5062 is capable of adequately competing for a niche with a human strain and survives in the human nose for at least 21 days.
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