ArticlePloS one2012
Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Higher risk of metabolic syndrome in children and adolescents and polymorphisms in the fat mass and obesity-associated gene: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis.Scientific reports · 2020Pooled it
- FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis.The American journal of clinical nutrition · 2016Pooled it
- FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome.Nutrients · 2023Review
- Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study.Scientific reports · 2021Article
- Whole Genome Interpretation for a Family of Five.Frontiers in genetics · 2021Article
- Childhood obesity and the associated rise in cardiometabolic complications.Nature metabolism · 2020Review
- Cohort Profile: The transition from childhood to adolescence in European children-how I.Family extends the IDEFICS cohort.International journal of epidemiology · 2017Article
- The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.PloS one · 2017Article
- Article
- Ghrelin.Molecular metabolism · 2015Review
- Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study.International journal of obesity (2005) · 2015Article
- Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.Molecular biology reports · 2014Article
- The bigger picture of FTO: the first GWAS-identified obesity gene.Nature reviews. Endocrinology · 2014Review
- A link between FTO, ghrelin, and impaired brain food-cue responsivity.The Journal of clinical investigation · 2013Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. POPULATION AND
methodsA cohort of 16224 children (2-9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1.
resultsAt T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all p<0.001) and with a statistically significant increased risk of overweight/obesity. Over the two year follow-up, no interaction between genotype and intervention was observed. The A allele was associated to a significantly higher increase in all the anthropometric variables examined at T0 independently from the study group (intervention versus control) (p-values: all p<0.002, adjusted for age, sex, country, intervention/control study group, T0 values, and individual time interval between T0 and T1). Over the two-year follow-up, 210 new cases of overweight/obesity occurred. A statistically significant higher incidence of overweight/obesity was associated to the A allele [OR(A) = 1.95, 95% CI = (1.29; 2.97)].
conclusionsWe confirmed the association between the FTO rs9939609 and body mass and overweight/obesity risk in European children. The main finding of the study is that the A allele carriers present higher increase of body mass and central adiposity over time and higher risk of developing overweight/obesity during growth, independently from intervention measures.
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