ArticlePloS one2012
Association of genetic loci with sleep apnea in European Americans and African-Americans: the Candidate Gene Association Resource (CARe).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring.Sleep · 2023Pooled it
- Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.American journal of respiratory cell and molecular biology · 2018Pooled it
- Evaluation of SIRT1 Protein Levels and SIRT1/rs7895833 Distributions in Turkish Patients With Obstructive Sleep Apnea.Journal of clinical laboratory analysis · 2025Article
- Oxytocin Receptor Polymorphism Is Associated With Sleep Apnea Symptoms.Journal of the Endocrine Society · 2024Article
- Genetic Predisposition to Elevated C-Reactive Protein and Risk of Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2024Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- A Scoping Review of Sleep Apnea: Where Do We Stand?Life (Basel, Switzerland) · 2023Article
- Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits.PLoS genetics · 2022Article
- Differences in Symptoms and Severity of Obstructive Sleep Apnea between Black and White Patients.Annals of the American Thoracic Society · 2022Article
- Empirical assessment of allele frequencies of genome wide association study variants associated with obstructive sleep apnea.American journal of translational research · 2022Article
- Gene variants associated with obstructive sleep apnea (OSA) in relation to sudden infant death syndrome (SIDS).International journal of legal medicine · 2021Article
- Article
- Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records.BMC medical genomics · 2020Article
- Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.Human molecular genetics · 2019Article
- Association between Obstructive Sleep Apnea and Cardiovascular Risk Factors: Variation by Age, Sex, and Race. The Multi-Ethnic Study of Atherosclerosis.Annals of the American Thoracic Society · 2018Article
- Genetic Ancestry for Sleep Research: Leveraging Health Inequalities to Identify Causal Genetic Variants.Chest · 2018Review
- The genetics of obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2018Review
- Determinants of racial/ethnic disparities in disordered sleep and obesity.Sleep health · 2017Article
- Risk of obstructive sleep apnea in African American patients with chronic rhinosinusitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Relation of Obstructive Sleep Apnea and a Common Variant at Chromosome 4q25 to Atrial Fibrillation.The American journal of cardiology · 2017Article
Corrections and comments
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Authors and funding
19 authors at 14 institutions in 3 countries.
Funding
Abstract
Although obstructive sleep apnea (OSA) is known to have a strong familial basis, no genetic polymorphisms influencing apnea risk have been identified in cross-cohort analyses. We utilized the National Heart, Lung, and Blood Institute (NHLBI) Candidate Gene Association Resource (CARe) to identify sleep apnea susceptibility loci. Using a panel of 46,449 polymorphisms from roughly 2,100 candidate genes on a customized Illumina iSelect chip, we tested for association with the apnea hypopnea index (AHI) as well as moderate to severe OSA (AHI≥15) in 3,551 participants of the Cleveland Family Study and two cohorts participating in the Sleep Heart Health Study.Among 647 African-Americans, rs11126184 in the pleckstrin (PLEK) gene was associated with OSA while rs7030789 in the lysophosphatidic acid receptor 1 (LPAR1) gene was associated with AHI using a chip-wide significance threshold of p-value<2×10(-6). Among 2,904 individuals of European ancestry, rs1409986 in the prostaglandin E2 receptor (PTGER3) gene was significantly associated with OSA. Consistency of effects between rs7030789 and rs1409986 in LPAR1 and PTGER3 and apnea phenotypes were observed in independent clinic-based cohorts.Novel genetic loci for apnea phenotypes were identified through the use of customized gene chips and meta-analyses of cohort data with replication in clinic-based samples. The identified SNPs all lie in genes associated with inflammation suggesting inflammation may play a role in OSA pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.