ArticlePloS one2012
Dysplasia-carcinoma transition specific transcripts in colonic biopsy samples.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Insights of Expression Profile of Chemokine Family in Inflammatory Bowel Diseases and Carcinogenesis.International journal of molecular sciences · 2024Article
- Gene regulatory network inference based on causal discovery integrating with graph neural network.Quantitative biology (Beijing, China) · 2023Article
- USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.The Journal of clinical investigation · 2023Article
- The Implications of Connexin 43 Deficiency during the Early Stages of Chemically Induced Mouse Colon Carcinogenesis.Antioxidants (Basel, Switzerland) · 2022Article
- A merged microarray meta-dataset for transcriptionally profiling colorectal neoplasm formation and progression.Scientific data · 2021Article
- Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapy.Scientific reports · 2021Article
- Immune Cells and Transcriptional Signatures Revealed Novel Regulators and Predict Clinical Response to Biologic Therapy in Ulcerative Colitis.Journal of cellular immunology · 2021Article
- SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer MetastasisFrontiers in oncology · 2021Article
- Identification of the hub genes in gastric cancer through weighted gene co-expression network analysis.PeerJ · 2021Article
- Promoter Hypomethylation and Increased Expression of the Long Non-coding RNA LINC00152 Support Colorectal Carcinogenesis.Pathology oncology research : POR · 2020Article
- Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis.Scientific reports · 2020Article
- Differential Expression Analysis Revealing CLCA1 to Be a Prognostic and Diagnostic Biomarker for Colorectal Cancer.Frontiers in oncology · 2020Article
- Identification of MicroRNA-Target Gene-Transcription Factor Regulatory Networks in Colorectal Adenoma Using Microarray Expression Data.Frontiers in genetics · 2020Article
- Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition.BMC cancer · 2019Article
- The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.JCI insight · 2018Article
- Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations.BMC cancer · 2018Article
- A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy.Laboratory investigation; a journal of technical methods and pathology · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early molecular detection of the dysplasia-carcinoma transition may enhance the strength of diagnosis in the case of colonic biopsies. Our aims were to identify characteristic transcript sets in order to develop diagnostic mRNA expression patterns for objective classification of benign and malignant colorectal diseases and to test the classificatory power of these markers on an independent sample set. METHODOLOGY/PRINCIPAL
findingsColorectal cancer (CRC) and adenoma specific transcript sets were identified using HGU133plus2 microarrays and 53 biopsies (22 CRC, 20 adenoma and 11 normal). Ninety-four independent biopsies (27 CRC, 29 adenoma and 38 normal) were analyzed on microarrays for testing the classificatory power of the discriminatory genes. Array real-time PCR validation was done on 68 independent samples (24 CRC, 24 adenoma and 20 normal). A set of 11 transcripts (including CXCL1, CHI3L1 and GREM1) was determined which could correctly discriminate between high-grade dysplastic adenoma and CRC samples by 100% sensitivity and 88.9% specificity. The discriminatory power of the marker set was proved to be high on independent samples in both microarray and RT-PCR analyses. 95.6% of original and 94.1% of cross-validated samples was correctly classified in discriminant analysis. CONCLUSIONS/SIGNIFICANCE: The identified transcripts could correctly characterize the dysplasia-carcinoma transition in biopsy samples, also on a large independent sample set. These markers can establish the basis of gene expression based diagnostic classification of colorectal cancer. Diagnostic RT-PCR cards can become part of the automated routine procedure.
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