ArticleInternational journal of medical sciences2012
Inhibitory effects of anthocyanins on secretion of Helicobacter pylori CagA and VacA toxins.
Article in International journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Unravelling the In Vitro and In Vivo Anti-Antioxidants (Basel, Switzerland) · 2022Article
- Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Colored Corn: An Up-Date on Metabolites Extraction, Health Implication, and Potential Use.Molecules (Basel, Switzerland) · 2021Review
- Fighting the Antibiotic Crisis: Flavonoids as Promising Antibacterial Drugs AgainstFrontiers in cellular and infection microbiology · 2021Review
- Limiting the pathogenesis of Salmonella Typhimurium with berry phenolic extracts and linoleic acid overproducing Lactobacillus casei.Journal of microbiology (Seoul, Korea) · 2020Article
- Inhibitory Effects of β-Caryophyllene onInternational journal of molecular sciences · 2020Article
- Frequency of Codon 306 Mutations inInternational journal of preventive medicine · 2020Review
- Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations.Scientific reports · 2019Article
- Inhibitory Effects of Menadione onInternational journal of molecular sciences · 2019Article
- Effect ofBioMed research international · 2019Article
- Antibacterial Properties of Four Novel Hit Compounds from a Methicillin-Resistant Staphylococcus aureus-Caenorhabditis elegans High-Throughput Screen.Microbial drug resistance (Larchmont, N.Y.) · 2018Article
- Antimicrobial Effect of Asiatic Acid AgainstFrontiers in microbiology · 2018Article
- Piperine treatment suppresses Helicobacter pylori toxin entry in to gastric epithelium and minimizes β-catenin mediated oncogenesis and IL-8 secretion in vitro.American journal of translational research · 2016Article
- Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review.European journal of nutrition · 2015Review
- Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.BioMed research international · 2015Review
- Cyanidin 3-O-glucoside reduces Helicobacter pylori VacA-induced cell death of gastric KATO III cells through inhibition of the SecA pathway.International journal of medical sciences · 2014Article
- Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells.Infectious agents and cancer · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anthocyanins have been studied as potential antimicrobial agents against Helicobacter pylori. We investigated whether the biosynthesis and secretion of cytotoxin-associated protein A (CagA) and vacuolating cytotoxin A (VacA) could be suppressed by anthocyanin treatment in vitro. H. pylori reference strain 60190 (CagA(+)/VacA(+)) was used in this study to investigate the inhibitory effects of anthocyanins; cyanidin 3-O-glucoside (C3G), peonidin 3-O-glucoside (Peo3G), pelargonidin 3-O-glucoside (Pel3G), and malvidin 3-O-glucoside (M3G) on expression and secretion of H. pylori toxins. Anthocyanins were added to bacterial cultures and Western blotting was used to determine secretion of CagA and VacA. Among them, we found that C3G inhibited secretion of CagA and VacA resulting in intracellular accumulation of CagA and VacA. C3G had no effect on cagA and vacA expression but suppressed secA transcription. As SecA is involved in translocation of bacterial proteins, the down-regulation of secA expression by C3G offers a mechanistic explanation for the inhibition of toxin secretion. To our knowledge, this is the first report suggesting that C3G inhibits secretion of the H. pylori toxins CagA and VacA via suppression of secA transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.