ArticleJournal of child neurology2013
Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network.
Article in Journal of child neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Adult and pediatric relapsing multiple sclerosis phase II and phase III trial design and their primary end points: A systematic review.Clinical and translational science · 2024Pooled it
- Dalfampridine in the treatment of multiple sclerosis: a meta-analysis of randomised controlled trials.Orphanet journal of rare diseases · 2021Pooled it
- Computer-assisted rehabilitation of attention in pediatric multiple sclerosis and ADHD patients: a pilot trial.BMC neurology · 2018Trial
- The Use of Patient-Reported Outcome Measures in Developmental Age: A Complementary Tool for Pediatric Multiple Sclerosis Prognosis.Neurology and therapy · 2026Review
- Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Age-Onset-Related Particularities of Pediatric MS-Understanding the Spectrum: A Tertiary Center Experience.Diseases (Basel, Switzerland) · 2025Article
- Functional and Structural Alterations in Pediatric Multiple Sclerosis: A Systematic Review and a Preliminary Activation Likelihood Estimation Functional Magnetic Resonance Imaging Meta-Analysis.Pediatric reports · 2025Review
- Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation.Brain communications · 2024Article
- Pretreatment Neurofilament Light Chain Serum Levels, Early Disease Severity, and Treatment Response in Pediatric Multiple Sclerosis.Neurology · 2023Article
- Pediatric Multiple Sclerosis: Changing the Trajectory of Progression.Current neurology and neuroscience reports · 2023Review
- The association between white matter tract structural connectivity and information processing speed in relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Quantitative Meta-analyses of Cognitive Abilities in Children With Pediatric-onset Multiple Sclerosis.Neuropsychology review · 2023Review
- Teriflunomide: Pediatric First Approval.Paediatric drugs · 2021Review
- Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis.Paediatric drugs · 2021Review
- A Randomized Computer-Assisted Rehabilitation Trial of Attention in Pediatric Multiple Sclerosis: A Post Hoc Analysis.Brain sciences · 2021Article
- Fingolimod as first-line treatment in pediatric-onset multiple sclerosis: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Cognitive Issues in Pediatric Multiple Sclerosis.Brain sciences · 2021Review
- Gray Matter Morphometry Correlates with Attentional Efficiency in Young-Adult Multiple Sclerosis.Brain sciences · 2021Article
- Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis.Neuropsychiatric disease and treatment · 2021Review
- The educational impact of childhood-onset multiple sclerosis: Why assessing academic achievement is imperative.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 9 institutions in 1 country.
Funding
Abstract
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.