ReviewAmerican journal of respiratory and critical care medicine2013
Pulmonary vascular complications of liver disease.
Review in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- AASLD AST Practice Guideline on adult liver transplantation: Candidate evaluation.Hepatology (Baltimore, Md.) · 2026Guideline
- Haemoptysis as a Presenting Manifestation of Hepatopulmonary Syndrome With Complete Resolution After Liver Transplantation.Respirology case reports · 2026Article
- Cryptogenic brain abscess: Right-to-left shunt in pulmonary arteriovenous malformation and hepatopulmonary syndrome.IDCases · 2026Article
- Hepatopulmonary Syndrome, Another Face of Dysregulated BMP9 Signaling.American journal of respiratory and critical care medicine · 2024Article
- Hepatopulmonary Syndrome: A Comprehensive Review.Cureus · 2024Review
- Synapomorphic features of hepatic and pulmonary vasculatures include comparable purinergic signaling responses in host defense and modulation of inflammation.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications.Nature reviews. Cardiology · 2021Review
- Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure.Comprehensive Physiology · 2019Review
- Article
- Treatment Barriers in Portopulmonary Hypertension.Hepatology (Baltimore, Md.) · 2019Review
- [Hepatopulmonary interactions].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Prolonged Unexplained Hypoxemia as Initial Presentation of Cirrhosis: A Case Report.The American journal of case reports · 2017Article
- Severe Hepatopulmonary Syndrome in a Child with Caroli Syndrome.Case reports in pediatrics · 2017Article
- Persistent Unexplained Dyspnea: A Case of Hepatopulmonary Syndrome.Case reports in cardiology · 2017Article
- Pulmonary complications of hepatic diseases.World journal of gastroenterology · 2016Review
- [Hepatocardiac disorders : Interactions between two organ systems].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Frequency of Hepatopulmonary Syndrome (HPS) Among Patients With Liver Cirrhosis: A Letter to Editor.Hepatitis monthly · 2016Article
- Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension.Biomedical reports · 2016Article
- CT Scan Does Not Differentiate Patients with Hepatopulmonary Syndrome from Other Patients with Liver Disease.PloS one · 2016Article
- The Art and Science of Diagnosing and Treating Lung and Heart Disease Secondary to Liver Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hepatopulmonary syndrome and portopulmonary hypertension are two pulmonary vascular complications of liver disease. The pathophysiology underlying each disorder is distinct, but patients with either condition may be limited by dyspnea. A careful evaluation of concomitant symptoms, the physical examination, pulmonary function testing and arterial blood gas analysis, and echocardiographic, imaging, and hemodynamic studies is crucial to establishing (and distinguishing) these diagnoses. Our understanding of the pathobiology, natural history, and treatment of these disorders has advanced considerably over the past decade; however, the presence of either still increases the risk of morbidity and mortality in patients with underlying liver disease. There is no effective medical treatment for hepatopulmonary syndrome. Although liver transplantation can resolve hepatopulmonary syndrome, there appears to be worse survival even with transplantation. Liver transplantation poses a very high risk of death in those with significant portopulmonary hypertension, where targeted medical therapies may improve functional status and allow successful transplantation in a small number of select patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.