Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013
Menstrual phase and depressive symptoms differences in physiological response to nicotine following acute smoking abstinence.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Pooled it
- Urge Coping Mediates the Relationship Between Physical Activity and Smoking Outcomes in a Sample of Premenopausal Women Intending to Quit Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Feasibility and acceptability of testing a menstrual-cycle timed smoking cessation intervention for women of reproductive age (Project Phase): Results of a pilot randomized control trial.Addictive behaviors · 2022Trial
- Differences in mood and cortisol by menstrual phase during acute smoking abstinence: A within-subject comparison.Experimental and clinical psychopharmacology · 2017Trial
- Subjective response to nicotine by menstrual phase.Addictive behaviors · 2015Trial
- Smoking- and menstrual-related symptomatology during short-term smoking abstinence by menstrual phase and depressive symptoms.Addictive behaviors · 2014Trial
- Acceptability of Hormonal Contraceptives as a Smoking Cessation Aid for Women of Reproductive Age: A Web-Based Cross-Sectional Survey.Women's health reports (New Rochelle, N.Y.) · 2024Article
- Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.Contemporary clinical trials communications · 2021Article
- Menstrual cycle phase, alcohol consumption, alcohol cravings, and mood among women in outpatient treatment for alcohol use disorder.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Response to nicotine following overnight smoking abstinence during short-term progesterone treatment in women.Experimental and clinical psychopharmacology · 2020Article
- Women and substance use disorders in low- and middle-income countries: A call for advancing research equity in prevention and treatment.Substance abuse · 2020Article
- Subjective response to intranasal nicotine administration in oral contraceptive users and naturally-cycling women.Addictive behaviors · 2019Article
- Ovarian hormones, menstrual cycle phase, and smoking: a review with recommendations for future studies.Current addiction reports · 2016Article
- Allopregnanolone association with psychophysiological and cognitive functions during acute smoking abstinence in premenopausal women.Experimental and clinical psychopharmacology · 2015Article
- Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking.Current addiction reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
introductionAccumulating evidence has linked depressive symptoms and sex hormones to risk for relapse; however, the specific mechanisms involved in these associations remain unknown. This randomized crossover study assessed physiological response to nicotine by menstrual phase in female smokers with and without depressive symptoms following acute smoking abstinence.
methodsFemales, ages 18-40 years with regular menstrual cycles, not on exogenous hormones or psychotropic medications, who reported smoking ≥ 5 cigarettes/day were enrolled. Participants were stratified into 2 groups: no depressive symptoms (NDS; n = 23) and depressive symptoms (DS; n = 24). After 4 days of biochemically verified smoking abstinence, participants completed 2 laboratory sessions in the follicular (F) and luteal (L) phases. Participants used nicotine nasal spray at Time 0, and blood pressure, heart rate, and serum nicotine were measured at Time -1, 5, 10, 20, 30, 45, 60, and 90 min.
resultsParticipants (n = 47) were 29.1 ± 6.8 years old and smoked an average of 12.5 ± 5.1 cigarettes/day. The NDS group had more pronounced menstrual phase differences (F > L) in diastolic blood pressure, heart rate, and maximum concentrations of nicotine compared with the DS group (p < .05).
conclusionsThis study observed an interaction between sex hormones and depressive symptoms such that those without depressive symptoms had a greater menstrual phase difference in the physiological response to nicotine. These data offer additional support for the role of sex hormones in the physiological response to nicotine, which may play a role in menstrual phase effects on smoking cessation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.