ArticleNucleic acids research2013
Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- The Lrs14 family of DNA-binding proteins as nucleoid-associated proteins in the Crenarchaeal order Sulfolobales.Molecular microbiology · 2025Review
- Bacterial histone HBb from Bdellovibrio bacteriovorus compacts DNA by bending.Nucleic acids research · 2024Article
- Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays.Nature communications · 2024Article
- Tethered Particle Motion Analysis of DNA-Binding Properties of Architectural Proteins.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Molecular contacts in the Cren7-DNA complex: A quantitative investigation for electrostatic interaction.Biophysical journal · 2023Article
- Article
- Interplay between Alba and Cren7 Regulates Chromatin Compaction inBiomolecules · 2022Article
- Mechanical and structural properties of archaeal hypernucleosomes.Nucleic acids research · 2021Article
- Archaea: The Final Frontier of Chromatin.Journal of molecular biology · 2021Review
- Archaeal transcription.Transcription · 2020Review
- Article
- Emerging views of genome organization in Archaea.Journal of cell science · 2020Review
- The Role of Archaeal Chromatin in Transcription.Journal of molecular biology · 2019Review
- An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea.Nucleic acids research · 2018Article
- Prespacer processing and specific integration in a Type I-A CRISPR system.Nucleic acids research · 2018Article
- Force and Scale Dependence of the Elasticity of Self-Assembled DNA Bottle Brushes.Macromolecules · 2018Article
- NQO-Induced DNA-Less Cell Formation Is Associated with Chromatin Protein Degradation and Dependent on AFrontiers in microbiology · 2017Article
- The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA.PloS one · 2017Article
- Diverse architectural properties of Sso10a proteins: Evidence for a role in chromatin compaction and organization.Scientific reports · 2016Article
- Insights into the interaction between Cren7 and DNA: the role of loop β3-β4.Extremophiles : life under extreme conditions · 2015Article
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Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Archaeal chromatin proteins share molecular and functional similarities with both bacterial and eukaryotic chromatin proteins. These proteins play an important role in functionally organizing the genomic DNA into a compact nucleoid. Cren7 and Sul7 are two crenarchaeal nucleoid-associated proteins, which are structurally homologous, but not conserved at the sequence level. Co-crystal structures have shown that these two proteins induce a sharp bend on binding to DNA. In this study, we have investigated the architectural properties of these proteins using atomic force microscopy, molecular dynamics simulations and magnetic tweezers. We demonstrate that Cren7 and Sul7 both compact DNA molecules to a similar extent. Using a theoretical model, we quantify the number of individual proteins bound to the DNA as a function of protein concentration and show that forces up to 3.5 pN do not affect this binding. Moreover, we investigate the flexibility of the bending angle induced by Cren7 and Sul7 and show that the protein-DNA complexes differ in flexibility from analogous bacterial and eukaryotic DNA-bending proteins.
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