ArticleThe Journal of biological chemistry2013
The retinol dehydrogenase Rdh10 localizes to lipid droplets during acyl ester biosynthesis.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Skeletal Muscle Mitochondria Contain Nuclear-Encoded RNA Species Prior to and Following Adaptation to Exercise Training in Rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Lipid droplets as cell fate determinants in skeletal muscle.Trends in endocrinology and metabolism: TEM · 2025Review
- Hif1α/Dhrs3a Pathway Participates in Lipid Droplet Accumulation via Retinol and Ppar-γ in Fish Hepatocytes.International journal of molecular sciences · 2023Article
- An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.EMBO reports · 2022Article
- PEX19 Coordinates Neutral Lipid Storage in Cells in a Peroxisome-Independent Fashion.Frontiers in cell and developmental biology · 2022Article
- Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation.Frontiers in pharmacology · 2022Review
- Characterization of subunit interactions in the hetero-oligomeric retinoid oxidoreductase complex.The Biochemical journal · 2021Article
- 17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury.Hepatology (Baltimore, Md.) · 2021Article
- Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity.Journal of lipid research · 2020Article
- Generation of Retinaldehyde for Retinoic Acid Biosynthesis.Biomolecules · 2019Review
- RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding.Cellular and molecular life sciences : CMLS · 2019Article
- Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.Biochemistry · 2018Article
- Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology.Current genetics · 2017Article
- Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases.Pharmacology & therapeutics · 2017Review
- The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-The Journal of biological chemistry · 2017Article
- Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential for Endoplasmic Reticulum to Outer Mitochondrial Membrane Protein Transport.Scientific reports · 2017Article
- Review
- Lipid droplets and steroidogenic cells.Experimental cell research · 2016Review
- Proteomic analysis of murine testes lipid droplets.Scientific reports · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Rdh10 catalyzes the first step of all-trans-retinoic acid biogenesis physiologically, conversion of retinol into retinal. We show that Rdh10 associates predominantly with mitochondria/mitochondrial-associated membrane (MAM) in the absence of lipid droplet biosynthesis, but also locates with lipid droplets during acyl ester biosynthesis. Targeting to lipid droplets requires the 32 N-terminal residues, which include a hydrophobic region followed by a net positive charge. Targeting to mitochondria/MAM and/or the stability of Rdh10 require both the N-terminal and the 48 C-terminal hydrophobic residues. Rdh10 behaves similarly to cellular retinol-binding protein, type 1, which also localizes to mitochondria/MAM before lipid droplet synthesis, and associates with lipid droplets during acyl ester synthesis (Jiang, W., and Napoli, J. L. (2012) Biochem. Biophys. Acta 1820, 859-8692). LRAT, an ER protein, also associates with lipid droplets upon acyl ester biosynthesis. Colocalization of Rdh10, Crbp1, and LRAT on lipid droplets suggests a metabolon that mediates retinol homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.