ArticleJournal of cellular physiology2013
Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes.
Article in Journal of cellular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Dietary indoles influence the AHR-RORγt axis and mucosal immune homeostasis in ART-treated SIV infection.JCI insight · 2026Article
- Dietary Indoles Modulate Gut Barrier Integrity via the AhR-IL-22 Axis in ART-Treated SIV Infection.bioRxiv : the preprint server for biology · 2025Article
- Simian Immunodeficiency Virus-Derived Extracellular Vesicles Induce a Chronic Inflammatory Phenotype in Healthy Astrocytes Unresolved by Anti-Retroviral Therapy.Pharmaceutics · 2025Article
- THC reverses SIV-induced senescence in astrocytes: possible compensatory mechanism against HIV associated brain injury?Frontiers in cellular neuroscience · 2025Article
- Article
- Transcriptional signatures of Zika virus infection in astrocytes.Journal of neurovirology · 2021Article
- Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components.Frontiers in aging neuroscience · 2021Article
- Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway.Acta pharmacologica Sinica · 2020Article
- Culture Model for Non-human Primate Choroid Plexus.Frontiers in cellular neuroscience · 2019Article
- A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Article
- αJournal of neuroinflammation · 2017Article
- Simulated blast overpressure induces specific astrocyte injury in an ex vivo brain slice model.PloS one · 2017Article
- The flavivirus dengue induces hypertrophy of white matter astrocytes.Journal of neurovirology · 2016Article
- Glial cell morphological and density changes through the lifespan of rhesus macaques.Brain, behavior, and immunity · 2016Article
- Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation.Journal of neurovirology · 2016Article
- Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research.Frontiers in cellular neuroscience · 2016Review
- Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques.Brain, behavior, and immunity · 2015Article
- Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus.Cellular and molecular neurobiology · 2015Article
- New advances on glial activation in health and disease.World journal of virology · 2015Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The foot processes of astrocytes cover over 60% of the surface of brain microvascular endothelial cells, regulating tight junction integrity. Retraction of astrocyte foot processes has been postulated to be a key mechanism in pathology. Therefore, movement of an astrocyte in response to a proinflammatory cytokine or even limited retraction of processes would result in leaky junctions between endothelial cells. Astrocytes lie at the gateway to the CNS and are instrumental in controlling leukocyte entry. Cultured astrocytes typically have a polygonal morphology until stimulated. We hypothesized that cultured astrocytes which were induced to stellate would have an activated phenotype compared with polygonal cells. We investigated the activation of astrocytes derived from adult macaques to the cytokine TNF-α under resting and stellated conditions by four parameters: morphology, intermediate filament expression, adhesion, and cytokine secretion. Astrocytes were stellated following transient acidification; resulting in increased expression of GFAP and vimentin. Stellation was accompanied by decreased adhesion that could be recovered with proinflammatory cytokine treatment. Surprisingly, there was decreased secretion of proinflammatory cytokines by stellated astrocytes compared with polygonal cells. These results suggest that astrocytes are capable of multiple phenotypes depending on the stimulus and the order stimuli are applied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.