ArticleJournal of radiation research2013
Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity.
Article in Journal of radiation research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- The revolutionary role of placental derivatives in biomedical research.Bioactive materials · 2025Review
- Article
- Plumping up a Cushion of Human Biowaste in Regenerative Medicine: Novel Insights into a State-of-the-Art Reserve Arsenal.Stem cell reviews and reports · 2022Review
- Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute forChinese herbal medicines · 2022Article
- Extracellular Vesicles (Secretomes) from Human Trophoblasts Promote the Regeneration of Skin Fibroblasts.International journal of molecular sciences · 2021Article
- Allogenic Use of Human Placenta-Derived Stromal Cells as a Highly Active Subtype of Mesenchymal Stromal Cells for Cell-Based Therapies.International journal of molecular sciences · 2021Review
- Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Human placental extract: the feasibility of translation from basic science into clinical practice.Annals of translational medicine · 2020Article
- Porcine placental extract facilitates memory and learning in aged mice.Food science & nutrition · 2019Article
- Anti‑apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro.International journal of molecular medicine · 2018Article
- Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects.Stem cells international · 2018Review
- The placental gateway of maternal transgenerational epigenetic inheritance.Journal of genetics · 2017Review
- PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies.Oncotarget · 2016Article
- Treatment of radiation-induced acute intestinal injury with bone marrow-derived mesenchymal stem cells.Experimental and therapeutic medicine · 2016Article
- Placenta Peptide Can Protect Mitochondrial Dysfunction through Inhibiting ROS and TNF-α Generation, by Maintaining Mitochondrial Dynamic Network and by Increasing IL-6 Level during Chronic Fatigue.Frontiers in pharmacology · 2016Article
- Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice.Scientific reports · 2015Article
- In vitro evaluation of the effects of human umbilical cord extracts on human fibroblasts, keratinocytes, and melanocytes.In vitro cellular & developmental biology. Animal · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placental extracts have been reported to have anti-oxidative and anti-inflammatory activities. Because there is increasing evidence that ionizing radiation induces the release of reactive oxygen species (ROS) and inflammatory cytokines, we examined the protective effects of a placental extract against radiation injury. C57BL/6 mice were exposed to 1 Gy of γ-ray radiation every day for 5 days, and placental extract (1 mg/day) was administrated orally soon after each exposure. At 2 days after the last irradiation, mice were euthanized to examine the numbers, colony-forming capacity, and DNA damage of stem/progenitor cells in the peripheral blood and bone marrow. To understand the related mechanisms, we also measured the levels of intracellular and mitochondrial ROS, and 8-OHdG in the plasma and urine, and IL-6 and TNF-α in the plasma. Compared with the placebo treatment, oral administration of placental extract significantly increased the number and colony-forming capacity, but decreased the DNA damage of bone marrow stem/progenitor cells. However, neither the levels of intracellular and mitochondrial ROS in bone marrow cells, nor the levels of 8-OHdG in the urine and plasma significantly differed between groups. Interestingly, in comparison with the placebo treatment, placental extract significantly decreased the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma. Placental extract significantly attenuated the acute radiation injury to bone marrow-derived stem/progenitor cells, and this protection is likely to be related to the anti-inflammatory activity of the placental extract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.