Evidence map›Paper›PMID 23154644›Full record

ReviewCurrent opinion in psychiatry2013

The expanding evidence base for rTMS treatment of depression.

Mark S George, Joseph J Taylor, E Baron Short

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 117 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 9 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03687892 naterminatednot on this mapstarted 2019, after this paper: background citation

Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation

TypeinterventionalSponsorStanford UniversityRan2019 to 2022Enrolled37ConditionsHealthy VolunteersArmscontinuous Theta Burst Stimulation, intermittent Theta Burst Stimulation
NCT03984201 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

Accelerated Theta Burst in Chronic Pain: A Biomarker Study

TypeinterventionalSponsorStanford UniversityRan2023 to 2024Enrolled0ConditionsChronic PainArmsIntermittent Theta Burst Stimulation (iTBS)
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 9 syntheses or guidelines pooled it, 289 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mark S GeorgePsychiatry Department, Brain Stimulation Laboratory, Medical University of South Carolina, and Ralph H. Johnson VA Medical Center, Charleston, South Carolina 29425, USA. georgem@musc.edu
Joseph J Taylor
E Baron Short
Medical University of South Carolina · US

Funding

Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced AnalgesiaF30DA033748 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TAYLOR, JOSEPH JEFFREY · 2012 to 2014
$119k
NIDA NIH HHS F30 DA033748
6 · The paper itself

Abstract

purpose of reviewDaily left prefrontal transcranial magnetic stimulation (TMS) for several weeks was first proposed as an acute treatment for depression in the early 1990s, and was Food and Drug Administration (FDA) approved in 2008. In the past year, several important studies have been published that extend our understanding of this novel treatment approach. RECENT

findingsThe first round of multisite clinical trials with TMS addressed whether prefrontal rTMS has efficacy and were conducted in carefully selected depressed patients who were antidepressant medication free. Several more recent studies assess the clinical effectiveness of TMS and report that about 35-40% of real-world patients who are commonly taking adjunctive antidepressants reach remission with a modest side effect profile. There are also new studies examining the durability of the TMS-induced antidepressant effect. Fifty-eight percent of TMS remitters remain remitted at 3-month follow-up. SUMMARY: These recent studies suggest that daily left prefrontal TMS over several weeks as a treatment for depression not only appears to have efficacy in rigorous randomized controlled trials, but is effective in real-world settings, with remission in 30-40% of patients. The TMS antidepressant effect, once achieved, appears to be as durable as with other antidepressant medications or interventions. Much more research is needed, particularly with issues such as the TMS coil location, stimulation intensity and frequency, and dosing strategy.

Indexed as

Depressive DisorderEvidence-Based MedicineHumansPrefrontal CortexRandomized Controlled Trials as TopicTranscranial Magnetic Stimulation

Identifiers

PMID23154644
PMCPMC4214363
OpenAlexW2064311536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.