ArticleEMBO reports2013
Silencing of proviruses in embryonic cells: efficiency, stability and chromatin modifications.
Article in EMBO reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Epigenetic mechanisms of retroviral regulation: a comparative review.Epigenetics & chromatin · 2026Review
- Article
- The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressingInternational journal of reproductive biomedicine · 2024Article
- Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells.Clinical epigenetics · 2023Article
- Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells.Viruses · 2020Article
- Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency.PLoS pathogens · 2020Article
- Article
- Related Endogenous Retrovirus-K Elements Harbor Distinct Protease Active Site Motifs.Frontiers in microbiology · 2018Article
- A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells.Nucleic acids research · 2017Article
- Inhibition of human endogenous retrovirus-K by antiretroviral drugs.Retrovirology · 2017Article
- Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry.Cell host & microbe · 2016Article
- Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells.Scientific reports · 2016Article
- Article
- Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice.Haematologica · 2015Article
- Article
- HIV-1 Is Restricted prior to Integration of Viral DNA in Primary Cord-Derived Human CD34+ Cells.Journal of virology · 2015Article
- Retrotransposons shape species-specific embryonic stem cell gene expression.Retrovirology · 2015Review
- Retroviral transcriptional regulation and embryonic stem cells: war and peace.Molecular and cellular biology · 2015Review
- The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses.Genes & development · 2015Article
- Hematopoietic Stem and Immune Cells in Chronic HIV Infection.Stem cells international · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic stem cells repress retroviral infection through transcriptional silencing of proviral DNAs. We characterized two distinct mechanisms of silencing in embryonic mouse cells infected by Moloney murine leukaemia virus (MLV): a highly efficient one targeting the proline transfer RNA primer-binding site (PBSpro), and a less efficient one operating independently of the PBS. Rare virus-expressing populations were isolated, and the timing and efficiency of establishment of silencing were determined. Superinfection of the selected virus-expressing cells with a second virus carrying a distinguishable reporter revealed that the PBSpro-directed silencing was still largely intact, whereas the PBS-independent silencing was partially reduced. The timing and stability of silencing, and the associated chromatin modifications on newly established and endogenous proviruses were determined. The results indicate that epigenetic mechanisms with different specificity and efficiency are used to silence the exogenous retroviral sequences in embryonic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.