ArticleEMBO reports2013
Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot.
Article in EMBO reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration.Molecular biology of the cell · 2025Article
- Nerve Growth Factor Signaling Tunes Axon Maintenance Protein Abundance and Kinetics of Wallerian Degeneration.bioRxiv : the preprint server for biology · 2025Article
- Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC.PLoS genetics · 2023Article
- Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.Human molecular genetics · 2022Article
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
- Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction.Cellular and molecular life sciences : CMLS · 2021Review
- The Ubiquitinated Axon: Local Control of Axon Development and Function by Ubiquitin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons.Nature communications · 2020Article
- Loss ofFrontiers in neurology · 2020Article
- The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.EMBO reports · 2019Article
- Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease.Frontiers in neuroscience · 2018Review
- NMNAT: It's an NADCurrent opinion in genetics & development · 2017Review
- NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.PLoS biology · 2016Article
- Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress.Nature communications · 2015Article
- Wallerian degeneration: an emerging axon death pathway linking injury and disease.Nature reviews. Neuroscience · 2014Review
- Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- NMNATs, evolutionarily conserved neuronal maintenance factors.Trends in neurosciences · 2013Review
- Chaperoning the synapse--NMNAT protects Bruchpilot from crashing.EMBO reports · 2013Article
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4 authors.
Funding
Abstract
Active zones are specialized presynaptic structures critical for neurotransmission. We show that a neuronal maintenance factor, nicotinamide mononucleotide adenylyltransferase (NMNAT), is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein, Bruchpilot (BRP), and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. NMNAT localizes to the peri-active zone and interacts biochemically with BRP in an activity-dependent manner. Loss of NMNAT results in ubiquitination, mislocalization and aggregation of BRP, and subsequent active zone degeneration. We propose that, as a neuronal maintenance factor, NMNAT specifically maintains active zone structure by direct protein-protein interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.