ReviewJournal of clinical research in pediatric endocrinology2013
Hyperthyroidism in childhood: causes, when and how to treat.
Review in Journal of clinical research in pediatric endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Predictors of Treatment Outcomes in Pediatric Graves' Disease.Journal of Korean medical science · 2026Article
- Cardiac Endocrine Function and Hormonal Interplay in Pediatrics: From Development to Clinical Implications.Biomedicines · 2025Review
- Study on serum TL1A levels and their correlation with Th17 cells, IL-17 and IL-21 in children with Graves' disease.Frontiers in immunology · 2024Article
- Increased incidence of Graves' disease during the COVID-19 pandemic in children and adolescents in the United States.Frontiers in endocrinology · 2024Article
- Article
- Beta-blocker Rebound Phenomenon in an Adolescent with Graves’ DiseaseJournal of clinical research in pediatric endocrinology · 2022Article
- Notes for the general paediatrician: managing thyrotoxicosis in children and young people.BMJ paediatrics open · 2022Review
- A Multicenter Retrospective Evaluation of Specialized Laboratory Investigations in the Workup of Pediatric Patients With New-Onset Supraventricular Tachycardia.Journal of emergency nursing · 2022Article
- Hyperthyroidism in children and adolescents: Experience in a university hospital in ColombiaBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Methimazole plus levothyroxine for treating hyperthyroidism in children: a systematic review and meta-analysis.Translational pediatrics · 2022Article
- Central TSH Dysregulation in a Patient with Familial Non-Autoimmune Autosomal Dominant Hyperthyroidism Due to a Novel Thyroid-Stimulating Hormone Receptor Disease-Causing Variant.Medicina (Kaunas, Lithuania) · 2021Article
- Report of a family with three generations of undiagnosed familial nonautoimmune hyperthyroidism.Endocrinology, diabetes & metabolism case reports · 2021Article
- Comprehensive Metabolomics Study in Children With Graves' Disease.Frontiers in endocrinology · 2021Article
- Role of thyroid hormones in craniofacial development.Nature reviews. Endocrinology · 2020Review
- Effects of hyperthyroidism in the development of the appendicular skeleton and muscles of zebrafish, with notes on evolutionary developmental pathology (Evo-Devo-Path).Scientific reports · 2019Article
- Change in BMI after radioactive iodine ablation for graves disease.International journal of pediatric endocrinology · 2017Article
- [Hyperthyroidism in children at the University Hospital in Dakar (Senegal)].The Pan African medical journal · 2017Article
- Pediatric Reference Intervals for Free Thyroxine and Free Triiodothyronine by Equilibrium Dialysis-Liquid Chromatography-Tandem Mass Spectrometry.Journal of clinical research in pediatric endocrinology · 2016Article
- A 3-year-old girl with Graves' disease with literature review.Annals of pediatric endocrinology & metabolism · 2014Article
- A new family with an activating mutation (G431S) in the TSH receptor gene: a phenotype discussion and review of the literature.International journal of pediatric endocrinology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graves' disease (GD) is the most common cause of hyperthyroidism in children. This review gives an overview and update of management of GD. Antithyroid drugs (ATD) are recommended as the initial treatment, but the major problem is the high relapse rate (30%) as remission is achieved after a first course of ATD. More prolonged medical treatment may increase the remission rate up to 50%. Alternative treatments, such as radioactive iodine or thyroidectomy, are considered in cases of relapse, lack of compliance, or ATD toxicity. Therefore, clinicians have sought prognostic indicators of remission. Relapse risk decreases with longer duration of the first course of ATD treatment, highlighting the positive impact of a long period of primary ATD treatment on outcome. The identification of other predictive factors such as severe biochemical hyperthyroidism at diagnosis, young age, and absence of other autoimmune conditions has made it possible to stratify patients according to the risk of relapse after ATD treatment, leading to improvement in patient management by facilitating the identification of patients requiring long-term ATD or early alternative therapy. Neonatal autoimmune hyperthyroidism is generally transient, occurring in only about 2% of the offspring of mothers with GD. Cardiac insufficiency, intrauterine growth retardation, craniostenosis, microcephaly and psychomotor disabilities are the major risks in these infants and highlight the importance of thyroid hormone receptor antibody determination throughout pregnancy in women with GD, as well as highlighting the need for early diagnosis and treatment of hyperthyroidism.
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