ArticleThe Journal of allergy and clinical immunology2013
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifieseLife · 2023Pooled it
- Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Associations Between Genetic Variants in the 17q21 Locus,Children (Basel, Switzerland) · 2026Article
- 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.American journal of respiratory and critical care medicine · 2024Article
- Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.The Journal of infectious diseases · 2023Article
- African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.Genome medicine · 2022Article
- Persistence of parental-reported asthma at early ages: A longitudinal twin study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Understanding How Asthma Starts: Longitudinal Patterns of Wheeze and the Chromosome 17q Locus.American journal of respiratory and critical care medicine · 2021Article
- Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.American journal of respiratory and critical care medicine · 2021Article
- The Role of Sphingolipids in Allergic Disorders.Frontiers in allergy · 2021Review
- Airway Epithelial Dysfunction in Asthma: Relevant to Epidermal Growth Factor Receptors and Airway Epithelial Cells.Journal of clinical medicine · 2020Review
- A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.The Journal of allergy and clinical immunology · 2018Review
- Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease.American journal of respiratory and critical care medicine · 2017Article
- Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort.The Journal of allergy and clinical immunology · 2016Article
- Airway reactivity and sphingolipids-implications for childhood asthma.Molecular and cellular pediatrics · 2015Article
- Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.The Journal of allergy and clinical immunology · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundGenome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma.
objectivesWe sought to determine whether associations in this region are specific to particular asthma phenotypes and specific to ORMDL3.
methodsWe examined associations between 244 independent single nucleotide polymorphisms (SNPs) plus 13 previously identified asthma-related SNPs in the region between 34 and 36 Mb on chromosome 17 and early wheezing phenotypes, doctor-diagnosed asthma and atopy at 7½ years, and bronchial hyperresponsiveness and lung function at 8½ years in 7045 children from the Avon Longitudinal Study of Parents and Children birth cohort study. With this, cis expression quantitative trait loci signals for the same SNPs were assessed in 875 samples across genes in the same region.
resultsThe strongest evidence for phenotypic association was seen for persistent wheezing (rs8076131 near ORMDL3: relative risk ratio [RRR], 1.60 [95% CI, 1.40-1.84], P = 1.4 × 10(-11); rs2305480 near GSDML: RRR, 1.60 [95% CI, 1.39-1.83], P = 1.5 × 10(-11); and rs9303277 near IKZF3: RRR, 1.57 [95% CI, 1.37-1.79], P = 4.4 × 10(-11)). Similar but less precisely estimated effects were seen for intermediate-onset wheeze, but there was little evidence of associations with other wheezing phenotypes. There was some evidence of associations with bronchial hyperresponsiveness. SNPs across the whole region show strong evidence of association with differential levels of expression at GSDML, IKZF3, and MED24, as well as ORMDL3.
conclusionsAssociations of SNPs in the 17q21 locus are specific to asthma and specific wheezing phenotypes and are not explained by associations with intermediate phenotypes, such as atopy or lung function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.