Evidence map›Paper›PMID 23153958›Full record

ReviewTrends in biochemical sciences2013

New insights into replisome fluidity during chromosome replication.

Isabel Kurth, Mike O'Donnell

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. The tomato gene Ty-6, encoding DNA polymerase delta subunit 1, confers broad resistance to Geminiviruses.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Plant DNA Polymerases.International journal of molecular sciences · 2019
    Review
  7. Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isabel KurthRockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA.
Mike O'Donnell

Funding

BIOCHEMICAL MECHANISM OF DNA POLYMERASE III HOLOENZYMER01GM038839 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI O'DONNELL, MICHAEL E · 1988 to 2014
$2.9M
BIOCHEMICAL MECHANISM OF DNA POLYMERASE III HOLOENZYMER37GM038839 · NIGMS · ROCKEFELLER UNIVERSITY · PI O'DONNELL, MICHAEL E · 1997 to 2006
$2.2M
Howard Hughes Medical InstituteNIGMS NIH HHS GM38839NIGMS NIH HHS R01 GM038839NIGMS NIH HHS R37 GM038839
6 · The paper itself

Abstract

Several paradigm shifting advances have recently been made on the composition and function of the chromosomal DNA replication machinery. Replisomes appear to be more fluid and dynamic than ever imagined, enabling rapid and efficient bypass of roadblocks and template lesions while faithfully replicating chromosomal DNA. This fluidity is determined by many layers of regulation, which reach beyond the role of replisome components themselves. In fact, recent studies show that additional polymerases, post-transcriptional modifications, and chromatin structure are required for complete chromosome duplication. Many of these factors are involved with the more complex events that take place during lagging-strand synthesis. These, and other recent discoveries, are the focus of this review.

Indexed as

DNA ReplicationReplication OriginChromatin Assembly and DisassemblyChromosomes, BacterialDNADNA, BacterialDNA-Directed DNA PolymeraseEscherichia coliEukaryotic CellsNucleosomesPhosphorylationProtein Processing, Post-TranslationalDNADNA, BacterialDNA-Directed DNA PolymeraseNucleosomesOkazaki fragments

Identifiers

PMID23153958
PMCPMC3597760

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.