ArticleDiabetes research and clinical practice2013
Association of retinol binding protein 4 with risk of gestational diabetes.
Article in Diabetes research and clinical practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Retinol-binding protein 4 (RBP4) circulating levels and gestational diabetes mellitus: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Blood retinol and retinol-binding protein concentrations are associated with diabetes: a systematic review and meta-analysis of observational studies.European journal of nutrition · 2022Pooled it
- Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.BMC pregnancy and childbirth · 2016Pooled it
- Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review.Metabolism: clinical and experimental · 2015Pooled it
- Impact of Serum Retinol-binding Protein 4 Levels in Late Pregnancy on the Incidence of Small/Large for Gestational Age Infants Among 11,854 Pregnant Women: A Retrospective Study.Journal of epidemiology · 2025Article
- Adipokines in Pregnancy: A Systematic Review of Clinical Data.Biomedicines · 2023Review
- Emerging Protein Biomarkers for the Diagnosis or Prediction of Gestational Diabetes-A Scoping Review.Journal of clinical medicine · 2021Article
- Sex dimorphism in the associations of gestational diabetes with cord blood adiponectin and retinol-binding protein 4.BMJ open diabetes research & care · 2020Article
- Adipokines in early and mid-pregnancy and subsequent risk of gestational diabetes: a longitudinal study in a multiracial cohort.BMJ open diabetes research & care · 2020Article
- Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study.Nutrition & metabolism · 2020Article
- Association between retinol-binding protein 4 concentrations and gestational diabetes mellitus (A1GDM and A2GDM) in different pregnancy and postpartum periods.Annals of translational medicine · 2019Article
- Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus.Current diabetes reports · 2017Review
- Are adipokines associated with gestational diabetes mellitus?Journal of the Turkish German Gynecological Association · 2016Article
- Is retinol binding protein 4 a link between adiposity and cancer?Hormone molecular biology and clinical investigation · 2015Review
- Inflammatory and Other Biomarkers: Role in Pathophysiology and Prediction of Gestational Diabetes Mellitus.International journal of molecular sciences · 2015Review
- Association of Leptin and Retinol Binding Protein 4 with the Risk of Gestational Diabetes: A Systematic Review and Meta-Analysis of Observational Studies.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimWe investigated association of maternal retinol binding protein 4 (RBP4) with risk of gestational diabetes (GDM).
methodsGDM cases (N=173) and controls (N=187) were selected from among participants of a cohort study of risk factors of pregnancy complications. Early pregnancy (16 weeks on average) serum RBP4 concentration was measured using an ELISA-based immunoassay. Logistic regression was used to estimate unadjusted and adjusted odds ratios (ORs/aORs) and 95% confidence intervals (95%CI).
resultsMean serum RBP4 was significantly higher among GDM cases compared with controls (47.1 vs. 41.1 μg/ml, respectively; p-value <0.05). Participants in the highest quartile for serum RBP4 had a 1.89-fold higher risk of GDM compared with participants in the lowest quartile (95%CI: 1.05-3.43). However, this relationship did not reach statistical significance after adjustment for confounders (aOR: 1.54; 95%CI: 0.82-2.90). Women who were ≥35 years old and who had high RBP4 (≥38.3 μg/ml, the median) had a 2.31-fold higher risk of GDM compared with women who were <35 years old and had low RBP4 (<38.3 μg/ml) (aOR: 2.31; 95%CI: 1.26-4.23; p-value for interaction=0.021).
conclusionOverall, there is modest evidence of a positive association of early pregnancy elevated RBP4 concentration with increased GDM risk, particularly among women with advanced age.
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