ArticleThe international journal of biochemistry & cell biology2013
Deletion of microRNA miR-223 increases Langerhans cell cross-presentation.
Article in The international journal of biochemistry & cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Absence of Langerhans cells resulted in over-influx of neutrophils and increased bacterial burden in skin wounds.Cell death & disease · 2024Article
- miR-223: An Immune Regulator in Infectious Disorders.Frontiers in immunology · 2021Review
- Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State.Frontiers in immunology · 2020Article
- Decreased microRNA-140-5p contributes to respiratory syncytial virus disease through targeting Toll-like receptor 4.Experimental and therapeutic medicine · 2018Article
- Differentially Tolerized Mouse Antigen Presenting Cells Share a Common miRNA Signature Including Enhanced mmu-miR-223-3p Expression Which Is Sufficient to Imprint a Protolerogenic State.Frontiers in pharmacology · 2018Article
- The development and function of dendritic cell populations and their regulation by miRNAs.Protein & cell · 2017Review
- Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers.Experimental dermatology · 2017Review
- Endogenous and tumour-derived microRNAs regulate cross-presentation in dendritic cells and consequently cytotoxic T cell function.Cytotechnology · 2016Review
- Article
- TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance.Allergy · 2016Review
- miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation.World journal of gastroenterology · 2016Review
- Altered microRNA expression in folliculotropic and transformed mycosis fungoides.Pathology oncology research : POR · 2015Article
- Nasal mucosal microRNA expression in children with respiratory syncytial virus infection.BMC infectious diseases · 2015Article
- microRNAs function in CD8+T cell biology.Journal of leukocyte biology · 2015Review
- MicroRNAs affect dendritic cell function and phenotype.Immunology · 2015Review
- The role of microRNAs in lymphopoiesis.International journal of hematology · 2014Review
- microRNA miR-17-92 cluster is highly expressed in epidermal Langerhans cells but not required for its development.Genes and immunity · 2014Article
- Dendritic Cell Plasticity in Tumor-Conditioned Skin: CD14(+) Cells at the Cross-Roads of Immune Activation and Suppression.Frontiers in immunology · 2013Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Langerhans cells (LCs) are skin-residential dendritic cells that regulate skin immunity. MicroRNAs (miRNAs) are key regulators in the control of biological functions in a variety of cell types. Deletion of all miRNAs interrupts the homeostasis and function of epidermal LCs. However, the roles of individual miRNAs in regulating LC development and function are still completely unknown. MiRNA miR-223 is especially expressed in the myeloid compartment. Here, we reported that miR-223 is highly expressed in freshly isolated epidermal LCs, and tested whether miR-223 regulates LC development and function using miR-223 knockout (KO) mice. We found that the number, maturation, migration and phagocytic capacity of LCs were comparable between miR-223KO and wild-type mice. However, lack of miR-223 significantly increases LCs-mediated antigen-specific CD8(+) T cell proliferation in vivo and in vitro, while LCs from KO and WT mice showed comparable stimulation for antigen-specific CD4(+) T cells. Our data suggest that miR-223 negatively regulates LC cross-presentation, but may not be required for normal LC homeostasis and development.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.