ArticleDevelopmental cell2012
Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 165 citations in OpenAlex.
- Single-cell transcriptional dynamics in a living vertebrate.Cell systems · 2026Article
- Cycles upon cycles-Temperature scaling of medaka development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- Progress in understanding the vertebrate segmentation clock.Nature reviews. Genetics · 2025Review
- Article
- DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics.Nature communications · 2025Article
- Article
- Nonreciprocal synchronization in embryonic oscillator ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Substrate Rigidity Modulates Segmentation Clock Dynamics in Isolated Presomitic Mesoderm Cells.bioRxiv : the preprint server for biology · 2024Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness.Development (Cambridge, England) · 2024Article
- Oscillatory control of embryonic development.Development (Cambridge, England) · 2024Review
- Microtubule polarity determines the lineage of embryonic neural precursor in zebrafish spinal cord.Communications biology · 2024Article
- Spatiotemporal control of pattern formation during somitogenesis.Science advances · 2024Review
- Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes.Nature communications · 2023Article
- Nfinder: automatic inference of cell neighborhood in 2D and 3D using nuclear markers.BMC bioinformatics · 2023Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Keeping development on time: Insights into post-transcriptional mechanisms driving oscillatory gene expression during vertebrate segmentation.Wiley interdisciplinary reviews. RNA · 2023Review
17 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Vertebrate body segmentation is controlled by the segmentation clock, a molecular oscillator involving transcriptional oscillations of cyclic genes in presomitic mesoderm cells. The rapid and highly dynamic nature of this oscillating system has proved challenging for study at the single-cell level. We achieved visualization of clock activity with a cellular level of resolution in living embryos, allowing direct comparison of oscillations in neighbor cells. We provide direct evidence that presomitic mesoderm cells oscillate asynchronously in zebrafish Notch pathway mutants. By tracking oscillations in mitotic cells, we reveal that a robust cell-autonomous, Notch-independent mechanism resumes oscillations after mitosis. Finally, we find that cells preferentially divide at a certain oscillation phase, likely reducing the noise generated by cell division in cell synchrony and suggesting an intriguing relationship between the mitotic cycle and clock oscillation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.