ArticleJournal of neurotrauma2013
Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice.
Article in Journal of neurotrauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Differences in pathological changes between two rat models of severe traumatic brain injury.Neural regeneration research · 2019Article
- Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.Biomaterials · 2017Article
- Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy.Journal of neurosurgery · 2016Article
- A New Rabbit Model of Pediatric Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.Comprehensive Physiology · 2015Review
- Traumatic brain injury using mouse models.Translational stroke research · 2014Review
- Elucidating the severity of preclinical traumatic brain injury models: a role for functional assessment?Neurosurgery · 2014Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
Traumatic brain injury (TBI) may involve diverse injury mechanisms (e.g., focal impact vs. diffuse impact loading). Putative therapies developed in TBI models featuring a single injury mechanism may fail in clinical trials if the model does not fully replicate multiple injury subtypes, which may occur concomitantly in a given patient. We report development and characterization of a mixed contusion/concussion TBI model in mice using controlled cortical impact (CCI; 0.6 mm depth, 6 m/sec) and a closed head injury (CHI) model at one of two levels of injury (53 vs. 83 g weight drop from 66 in). Compared with CCI or CHI alone, sequential CCI-CHI produced additive effects on loss of consciousness (p<0.001), acute cell death (p<0.05), and 12-day lesion size (p<0.05) but not brain edema or 48-h contusion volume. Additive effects of CHI and CCI on post-injury motor (p<0.05) and cognitive (p<0.005) impairment were observed with sequential CCI-CHI (83 g). The data suggest that concussive forces, which in isolation do not induce histopathological damage, exacerbate histopathology and functional outcome after cerebral contusion. Sequential CHI-CCI may model complex injury mechanisms that occur in some patients with TBI and may prove useful for testing putative therapies.
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Registered trials
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