ArticleGenome biology2012
Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Review
- Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction.Journal of Zhejiang University. Science. B · 2023Review
- Acquisition of new function through gene duplication in the metallocarboxypeptidase family.Scientific reports · 2023Article
- Downregulation of miR-185 is a common pathogenic event in 22q11.2 deletion syndrome-related and idiopathic schizophrenia.Metabolic brain disease · 2022Article
- Identification and Analysis ofFrontiers in aging neuroscience · 2022Article
- Crucial Roles of miR-625 in Human Cancer.Frontiers in medicine · 2022Review
- Systematic functional interrogation of human pseudogenes using CRISPRi.Genome biology · 2021Article
- Enhancer Function of MicroRNA-3681 Derived from Long Terminal Repeats Represses the Activity of Variable Number Tandem Repeats in the 3' UTR ofMolecules and cells · 2020Article
- Transcriptional activity and strain-specific history of mouse pseudogenes.Nature communications · 2020Article
- Regulation of gene expression by cis-acting long non-coding RNAs.Nature reviews. Genetics · 2020Review
- Re-recognition of pseudogenes: From molecular to clinical applications.Theranostics · 2020Review
- Non-Coding RNAs and their Integrated Networks.Journal of integrative bioinformatics · 2019Review
- Identification of competitive endogenous RNAs network in breast cancer.Cancer medicine · 2019Article
- Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis.Molecular biology and evolution · 2018Article
- Chromosome-level reference genome and alternative splicing atlas of moso bamboo (Phyllostachys edulis).GigaScience · 2018Article
- TUSC2P suppresses the tumor function of esophageal squamous cell carcinoma by regulating TUSC2 expression and correlates with disease prognosis.BMC cancer · 2018Article
- Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk.Critical reviews in biochemistry and molecular biology · 2018Review
- Interaction and cross-talk between non-coding RNAs.Cellular and molecular life sciences : CMLS · 2018Review
- A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes.Genome biology · 2017Article
- A Macro View of MicroRNAs: The Discovery of MicroRNAs and Their Role in Hematopoiesis and Hematologic Disease.International review of cell and molecular biology · 2017Review
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
Abstract
backgroundRecent reports have highlighted instances of mRNAs that, in addition to coding for protein, regulate the abundance of related transcripts by altering microRNA availability. These two mRNA roles - one mediated by RNA and the other by protein - are inter-dependent and hence cannot easily be separated. Whether the RNA-mediated role of transcripts is important, per se, or whether it is a relatively innocuous consequence of competition by different transcripts for microRNA binding remains unknown.
resultsHere we took advantage of 48 loci that encoded proteins in the earliest eutherian ancestor, but whose protein-coding capability has since been lost specifically during rodent evolution. Sixty-five percent of such loci, which we term 'unitary pseudogenes', have retained their expression in mouse and their transcripts exhibit conserved tissue expression profiles. The maintenance of these unitary pseudogenes' spatial expression profiles is associated with conservation of their microRNA response elements and these appear to preserve the post-transcriptional roles of their protein-coding ancestor. We used mouse Pbcas4, an exemplar of these transcribed unitary pseudogenes, to experimentally test our genome-wide predictions. We demonstrate that the role of Pbcas4 as a competitive endogenous RNA has been conserved and has outlived its ancestral gene's loss of protein-coding potential.
conclusionsThese results show that post-transcriptional regulation by bifunctional mRNAs can persist over long evolutionary time periods even after their protein coding ability has been lost.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.