ArticlePediatric rheumatology online journal2012
CLARITY - ChiLdhood Arthritis Risk factor Identification sTudY.
Article in Pediatric rheumatology online journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.Rheumatology (Oxford, England) · 2022Pooled it
- The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status.Pediatric rheumatology online journal · 2024Article
- Age and Sex Specific Trends in Incidence of Juvenile Idiopathic Arthritis in Danish Birth Cohorts from 1992 to 2002: A Nationwide Register Linkage Study.International journal of environmental research and public health · 2021Article
- Genomic risk scores for juvenile idiopathic arthritis and its subtypes.Annals of the rheumatic diseases · 2020Article
- Appropriate age range for introduction of complementary feeding into an infant's diet.EFSA journal. European Food Safety Authority · 2019Article
- Review of environmental factors and juvenile idiopathic arthritis.Open access rheumatology : research and reviews · 2019Review
- Extensive Ethnic Variation and Linkage Disequilibrium at theFrontiers in immunology · 2019Article
- Vitamin D and juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2018Review
- Early feeding and risk of Juvenile idiopathic arthritis: a case control study in a prospective birth cohort.Pediatric rheumatology online journal · 2017Article
- A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities.Pediatric rheumatology online journal · 2017Article
- Environmental Risk Factors and Early-Life Exposures in Juvenile Idiopathic Arthritis: A Case-Control Study.Arthritis care & research · 2016Article
- Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis.Archives of disease in childhood · 2016Article
- Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.BMC medical genetics · 2016Article
- The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.Genes and immunity · 2015Article
- DNA methylation at IL32 in juvenile idiopathic arthritis.Scientific reports · 2015Article
- Management of juvenile idiopathic arthritis: hitting the target.Nature reviews. Rheumatology · 2015Review
- Juvenile idiopathic arthritis in relation to maternal prenatal smoking.Arthritis care & research · 2015Article
- Independent confirmation of juvenile idiopathic arthritis genetic risk loci previously identified by immunochip array analysis.Pediatric rheumatology online journal · 2014Article
- Polyarticular juvenile idiopathic arthritis - epidemiology and management approaches.Clinical epidemiology · 2014Review
- Independent replication analysis of genetic loci with previous evidence of association with juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundThe aetiology of juvenile idiopathic arthritis (JIA) is largely unknown. We have established a JIA biobank in Melbourne, Australia called CLARITY - ChiLdhood Arthritis Risk factor Identification sTudY, with the broad aim of identifying genomic and environmental disease risk factors. We present here study protocols, and a comparison of socio-demographic, pregnancy, birth and early life characteristics of cases and controls collected over the first 3 years of the study.
methodsCases are children aged ≤18 years with a diagnosis of JIA by 16 years. Controls are healthy children aged ≤18 years, born in the state of Victoria, undergoing a minor elective surgical procedure. Participant families provide clinical, epidemiological and environmental data via questionnaire, and a blood sample is collected.
resultsClinical characteristics of cases (n = 262) are similar to those previously reported. Demographically, cases were from families of higher socio-economic status. After taking this into account, the residual pregnancy and perinatal profiles of cases were similar to control children. No case-control differences in breastfeeding commencement or duration were detected, nor was there evidence of increased case exposure to tobacco smoke in utero. At interview, cases were less likely to be exposed to active parental smoking, but disease-related changes to parent behaviour may partly underlie this.
conclusionsWe show that, after taking into account socio-economic status, CLARITY cases and controls are well matched on basic epidemiological characteristics. CLARITY represents a new study platform with which to generate new knowledge as to the environmental and biological risk factors for JIA.
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Registered trials
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