ArticlePloS one2012
Involvement of Aquaporin 3 in Helicobacter pylori-related gastric diseases.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer.International journal of molecular sciences · 2024Review
- Clinical value and molecular mechanism of AQGPs in different tumors.Medical oncology (Northwood, London, England) · 2022Review
- Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases.Frontiers in genetics · 2021Review
- Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.Pathology oncology research : POR · 2020Review
- Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA-MB-231 breast cancer cell line.Oncology letters · 2018Article
- Article
- EnterotoxigenicIranian journal of veterinary research · 2018Article
- Involvement of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Repressor inJournal of Cancer · 2018Article
- Tumor necrosis factorPhysiological reports · 2017Article
- Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines.International journal of molecular sciences · 2016Review
- The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3β/β-catenin pathway.Oncotarget · 2016Article
- Potential role of aquaporin 3 in gastric intestinal metaplasia.Oncotarget · 2015Article
- Hyperglycemia Promotes Human Gastric Carcinoma Progression via Aquaporin 3.Digestive diseases and sciences · 2015Article
- miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer.Journal of gastroenterology · 2014Article
- Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer.Journal of experimental & clinical cancer research : CR · 2014Article
- Gastric cancer-molecular and clinical dimensions.Nature reviews. Clinical oncology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer is one of the most common and lethal malignant cancers worldwide, and numerous epidemiological studies have demonstrated that Helicobacter pylori (H. pylori) infection plays a key role in the development of gastric carcinomas. Our previous studies showed that aquaporin 3 (AQP3) is overexpressed in gastric carcinoma and promotes the migration and proliferation of human gastric carcinoma cells, suggesting that AQP3 may be a potentially important determinant of gastric carcinoma. However, the role of AQP3 in H. pylori carcinogenesis is unknown.
methodsThe AQP3 protein and H. pylori were detected in human gastric tissues by immunohistochemistry and modified Giemsa staining respectively. AQP3 knockdown was obtained by small interfering (si) RNA. Western blot assays and RT-PCR were used to evaluate the change of AQP3 in the human gastric cancer AGS and SGC7901 cell lines after co-culture with H. pylori. Sprague Dawley rats were orally inoculated with H. pylori to establish a rat model colonized by H. pylori.
resultsThe present study found that AQP3 expression correlated with H. pylori infection status in gastric cancer tissues and corresponding normal mucosa, and H. pylori co-culture upregulated AQP3 expression in human gastric adenocarcinoma cells in vitro via the extracellular signal-regulated kinase signaling pathway. H. pylori infection also increased AQP3 expression in gastric mucosa colonized by H. pylori in a Sprague Dawley rat model.
conclusionsThese findings provide further information to understand the mechanism of H. pylori carcinogenesis and a potential strategy for the treatment of H. pylori-associated gastric carcinoma.
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