ArticlePloS one2012
The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Social Media Popularity and Academic Productivity in Academic Plastic Surgery: A Positive Correlation.Aesthetic plastic surgery · 2023Article
- Chronic Systemic Dexamethasone Regulates the Mineralocorticoid/Glucocorticoid Pathways Balance in Rat Ocular Tissues.International journal of molecular sciences · 2022Article
- Article
- Aldose reductase mediates retinal microglia activation.Biochemical and biophysical research communications · 2016Article
- Sustained-release steroids for the treatment of diabetic macular edema.Current diabetes reports · 2015Review
- Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone.BioMed research international · 2015Review
- Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.Investigative ophthalmology & visual science · 2014Article
- Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation.Molecular vision · 2014Article
- Article
- Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation.Cell death and differentiation · 2013Article
- Effect of spironolactone on cardiac remodeling after acute myocardial infarction.World journal of emergency medicine · 2013Article
- Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.Advances in experimental medicine and biologyReview
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the eye is a mineralocorticoid-sensitive organ and we now question the role of mineralocorticoid receptor (MR) in ocular inflammation. The endotoxin-induced uveitis (EIU), a rat model of human intraocular inflammation, was induced by systemic administration of lipopolysaccharide (LPS). Evaluations were made 6 and 24 hours after intraocular injection of aldosterone (simultaneous to LPS injection). Three hours after onset of EIU, the MR and the glucocorticoid metabolizing enzyme 11-beta hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression were down-regulated in iris/ciliary body and the corticosterone concentration was increased in aqueous humor, altering the normal MR/glucocorticoid receptor (GR) balance. At 24 hours, the GR expression was also decreased. In EIU, aldosterone reduced the intensity of clinical inflammation in a dose-dependent manner. The clinical benefit of aldosterone was abrogated in the presence of the MR antagonist (RU26752) and only partially with the GR antagonist (RU38486). Aldosterone reduced the release of inflammatory mediators (6 and 24 hours: TNF-α, IFN-γ, MIP-1α) in aqueous humor and the number of activated microglia/macrophages. Aldosterone partly prevented the uveitis-induced MR down-regulation. These results suggest that MR expression and activation in iris/ciliary body could protect the ocular structures against damages induced by EIU.
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