ArticlePloS one2012
Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Serum osteopontin as a diagnostic marker for missed abortion: evidence from a prospective study.Journal of the Turkish German Gynecological Association · 2026Article
- Identification and Validation of Genes Involved in Energy Metabolism in Polycystic Ovary Syndrome.Iranian journal of biotechnology · 2025Article
- MicroRNAs, endometrial receptivity and molecular pathways.Reproductive biology and endocrinology : RB&E · 2024Review
- Gene expression profile analysis of subregions of the adult female reproductive tract in the brown anole, Anolis sagrei.Reproduction (Cambridge, England) · 2024Article
- Regulatory effects of Zishen Yutai Pill on endometrial epithelial response in vitro in immunology microenvironment.Heliyon · 2023Article
- Transcriptome profiling analysis of uterus during chicken laying periods.BMC genomics · 2023Article
- DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Transcriptome Analysis of the Ovaries of Taihe Black-Bone Silky Fowls at Different Egg-Laying Stages.Genes · 2022Article
- Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation.Reproductive biology and endocrinology : RB&E · 2022Review
- Dynamic Changes of Gene Expression in Mouse Mural Trophectoderm Regulated byFrontiers in cell and developmental biology · 2022Article
- Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Article
- Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy.Canadian respiratory journal · 2017Article
- Deep sequencing of transcriptome profiling of GSTM2 knock-down in swine testis cells.Scientific reports · 2016Article
- Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function.Scientific reports · 2016Article
- Microvascular density and vascular endothelial growth factor and osteopontin expression during the implantation window in a controlled ovarian hyperstimulation rat model.Experimental and therapeutic medicine · 2015Article
- Article
- Bisphenol a influences blastocyst implantation via regulating integrin β3 and trophinin expression levels.International journal of clinical and experimental medicine · 2015Article
- Hormonal Fluctuations during the Estrous Cycle Modulate Heme Oxygenase-1 Expression in the Uterus.Frontiers in endocrinology · 2014Article
- Osteopontin is expressed in the mouse uterus during early pregnancy and promotes mouse blastocyst attachment and invasion in vitro.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryo implantation is a highly orchestrated process that involves blastocyst-uterine interactions. This process is confined to a defined interval during gestation referred to as the "window of embryo implantation receptivity". In mice this receptive period is controlled by ovarian estrogen and involves a coordination of blastocyst adhesion competence and uterine receptivity. Mechanisms coordinating the acquisition of blastocyst adhesion competence and uterine receptivity are largely unknown. Here, we show that ovarian estrogen indirectly regulates blastocyst adhesion competence. Acquisition of blastocyst adhesion competence was attributed to integrin activation (e.g. formation of adhesion complexes) rather than de novo integrin synthesis. Osteopontin (OPN) was identified as an estrogen-dependent uterine endometrial gland secretory factor responsible for activating blastocyst adhesion competence. Increased adhesion complex assembly in OPN-treated blastocysts was mediated through focal adhesion kinase (FAK)- and phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathways. These findings define for the first time specific regulatory components of an estrogen-dependent pathway coordinating blastocyst adhesion competence and uterine receptivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.